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Novel betulin dicarboxylic acid ester derivatives as potent antiviral agents: Design, synthesis, biological evaluation, structure-activity relationship and in-silico study.
Pecak, Pawel; Orzechowska, Beata; Chrobak, Elwira; Boryczka, Stanislaw.
Affiliation
  • Pecak P; Department of Organic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 4 Jagiellonska Str., 41-200, Sosnowiec, Poland. Electronic address: chemorg@sum.edu.pl.
  • Orzechowska B; Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Laboratory of Virology, 12 Rudolfa Weigla Str., 53-114, Wroclaw, Poland. Electronic address: beata.orzechowska@hirszfeld.pl.
  • Chrobak E; Department of Organic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 4 Jagiellonska Str., 41-200, Sosnowiec, Poland. Electronic address: echrobak@sum.edu.pl.
  • Boryczka S; Department of Organic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 4 Jagiellonska Str., 41-200, Sosnowiec, Poland. Electronic address: boryczka@sum.edu.pl.
Eur J Med Chem ; 225: 113738, 2021 Dec 05.
Article in En | MEDLINE | ID: mdl-34425312
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Triterpenes / Drug Design / Dicarboxylic Acids / Esters Language: En Journal: Eur J Med Chem Year: 2021 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Triterpenes / Drug Design / Dicarboxylic Acids / Esters Language: En Journal: Eur J Med Chem Year: 2021 Document type: Article Country of publication: