Susceptibility of CTLA-4 -1661A/G polymorphism towards severity of rheumatic heart disease.
Indian Heart J
; 73(4): 511-515, 2021.
Article
in En
| MEDLINE
| ID: mdl-34474769
ABSTRACT
AIM:
Genetic contribution in acute rheumatic fever (ARF)/rheumatic heart disease (RHD) has been suggested but not according to severity of the valve involvement. This study attempts to identify the relevance of CTLA-4 polymorphism with severity of the disease.METHODS:
In a case-control design, 291 healthy controls and 83 patients were genotyped for association between RHD and single-nucleotide polymorphisms -1661A/G of CTLA-4.RESULTS:
Segregation of patients on the basis of severity i.e., MVL (Mitral Valve Lesion) and CVL (Combined Valve Lesion) revealed that the frequency of CTLA-4 -1661G allele depleted as the disease progressed to CVL (p < 0.05). Patients in the age group of 31-45 years were significantly more susceptible (p < 0.046). Whereas, female patients were more susceptible than the male patients.CONCLUSION:
Our study suggests the risk associated with decreased frequency of CTLA-4 -1661G allele in the CVL group and in females.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rheumatic Fever
/
Rheumatic Heart Disease
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Indian Heart J
Year:
2021
Document type:
Article
Affiliation country: