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The linear plasmid pSA3239 is essential for the replication of the Streptomyces lavendulae subsp. lavendulae CCM 3239 chromosome.
Novakova, Renata; Rückert, Christian; Knirschova, Renata; Feckova, Lubomira; Busche, Tobias; Csolleiova, Dominika; Homerova, Dagmar; Rezuchova, Bronislava; Javorova, Rachel; Sevcikova, Beatrica; Kalinowski, Jörn; Kormanec, Jan.
Affiliation
  • Novakova R; Institute of Molecular Biology, Slovak Academy of Sciences, 845 51 Bratislava, Slovak Republic. Electronic address: renata.novakova@savba.sk.
  • Rückert C; Center for Biotechnology (CeBiTec), Universität Bielefeld, Bielefeld, Germany. Electronic address: cruecker@cebitec.uni-bielefeld.de.
  • Knirschova R; Institute of Molecular Biology, Slovak Academy of Sciences, 845 51 Bratislava, Slovak Republic. Electronic address: renata.knirschova@savba.sk.
  • Feckova L; Institute of Molecular Biology, Slovak Academy of Sciences, 845 51 Bratislava, Slovak Republic. Electronic address: lubomira.feckova@savba.sk.
  • Busche T; Center for Biotechnology (CeBiTec), Universität Bielefeld, Bielefeld, Germany. Electronic address: tbusche@cebitec.uni-bielefeld.de.
  • Csolleiova D; Institute of Molecular Biology, Slovak Academy of Sciences, 845 51 Bratislava, Slovak Republic. Electronic address: dominika.csolleiova@savba.sk.
  • Homerova D; Institute of Molecular Biology, Slovak Academy of Sciences, 845 51 Bratislava, Slovak Republic. Electronic address: dagmar.homerova@savba.sk.
  • Rezuchova B; Institute of Molecular Biology, Slovak Academy of Sciences, 845 51 Bratislava, Slovak Republic. Electronic address: bronislava.rezuchova@savba.sk.
  • Javorova R; Institute of Molecular Biology, Slovak Academy of Sciences, 845 51 Bratislava, Slovak Republic. Electronic address: rachel.javorova@savba.sk.
  • Sevcikova B; Institute of Molecular Biology, Slovak Academy of Sciences, 845 51 Bratislava, Slovak Republic. Electronic address: beatrica.sevcikova@savba.sk.
  • Kalinowski J; Center for Biotechnology (CeBiTec), Universität Bielefeld, Bielefeld, Germany. Electronic address: joern@cebitec.uni-bielefeld.de.
  • Kormanec J; Institute of Molecular Biology, Slovak Academy of Sciences, 845 51 Bratislava, Slovak Republic. Electronic address: jan.kormanec@savba.sk.
Res Microbiol ; 172(6): 103870, 2021.
Article in En | MEDLINE | ID: mdl-34487842
We previously reported the complete genome of Streptomyces lavendulae subsp. lavendulae CCM 3239, containing the linear chromosome and the large linear plasmid pSA3239. Although the chromosome exhibited replication features characteristic for the archetypal end-patching replication, it lacked the tap/tpg gene pair for two proteins essential for this process. However, this archetypal tpgSa-tapSa operon is present in pSA3239. Complete genomic sequence of the S. lavendulae Del-LP strain lacking this plasmid revealed the circularization of its chromosome with a large deletion of both arms. These results suggest an essential role of pSA3239-encoded TapSa/TpgSa in the end-patching replication of the chromosome.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmids / Streptomyces / Bacterial Proteins / Chromosomes, Bacterial Language: En Journal: Res Microbiol Journal subject: MICROBIOLOGIA Year: 2021 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmids / Streptomyces / Bacterial Proteins / Chromosomes, Bacterial Language: En Journal: Res Microbiol Journal subject: MICROBIOLOGIA Year: 2021 Document type: Article Country of publication: