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Selective Acetyl-CoA Carboxylase 1 Inhibitor Improves Hepatic Steatosis and Hepatic Fibrosis in a Preclinical Nonalcoholic Steatohepatitis Model.
Tamura, Yumiko Okano; Sugama, Jun; Iwasaki, Shinji; Sasaki, Masako; Yasuno, Hironobu; Aoyama, Kazunobu; Watanabe, Masanori; Erion, Derek M; Yashiro, Hiroaki.
Affiliation
  • Tamura YO; Cardiovascular and Metabolic Drug Discovery Unit (Y.O.T., J.S., M.W.), Drug Metabolism & Pharmacokinetics Research Laboratories (S.I., K.A.), Biomolecular Research Laboratories (M.S.), and Drug Safety Research Laboratories (H.Yasu.), Takeda Pharmaceutical Company Limited, Kanagawa, Japan; and Ga
  • Sugama J; Cardiovascular and Metabolic Drug Discovery Unit (Y.O.T., J.S., M.W.), Drug Metabolism & Pharmacokinetics Research Laboratories (S.I., K.A.), Biomolecular Research Laboratories (M.S.), and Drug Safety Research Laboratories (H.Yasu.), Takeda Pharmaceutical Company Limited, Kanagawa, Japan; and Ga
  • Iwasaki S; Cardiovascular and Metabolic Drug Discovery Unit (Y.O.T., J.S., M.W.), Drug Metabolism & Pharmacokinetics Research Laboratories (S.I., K.A.), Biomolecular Research Laboratories (M.S.), and Drug Safety Research Laboratories (H.Yasu.), Takeda Pharmaceutical Company Limited, Kanagawa, Japan; and Ga
  • Sasaki M; Cardiovascular and Metabolic Drug Discovery Unit (Y.O.T., J.S., M.W.), Drug Metabolism & Pharmacokinetics Research Laboratories (S.I., K.A.), Biomolecular Research Laboratories (M.S.), and Drug Safety Research Laboratories (H.Yasu.), Takeda Pharmaceutical Company Limited, Kanagawa, Japan; and Ga
  • Yasuno H; Cardiovascular and Metabolic Drug Discovery Unit (Y.O.T., J.S., M.W.), Drug Metabolism & Pharmacokinetics Research Laboratories (S.I., K.A.), Biomolecular Research Laboratories (M.S.), and Drug Safety Research Laboratories (H.Yasu.), Takeda Pharmaceutical Company Limited, Kanagawa, Japan; and Ga
  • Aoyama K; Cardiovascular and Metabolic Drug Discovery Unit (Y.O.T., J.S., M.W.), Drug Metabolism & Pharmacokinetics Research Laboratories (S.I., K.A.), Biomolecular Research Laboratories (M.S.), and Drug Safety Research Laboratories (H.Yasu.), Takeda Pharmaceutical Company Limited, Kanagawa, Japan; and Ga
  • Watanabe M; Cardiovascular and Metabolic Drug Discovery Unit (Y.O.T., J.S., M.W.), Drug Metabolism & Pharmacokinetics Research Laboratories (S.I., K.A.), Biomolecular Research Laboratories (M.S.), and Drug Safety Research Laboratories (H.Yasu.), Takeda Pharmaceutical Company Limited, Kanagawa, Japan; and Ga
  • Erion DM; Cardiovascular and Metabolic Drug Discovery Unit (Y.O.T., J.S., M.W.), Drug Metabolism & Pharmacokinetics Research Laboratories (S.I., K.A.), Biomolecular Research Laboratories (M.S.), and Drug Safety Research Laboratories (H.Yasu.), Takeda Pharmaceutical Company Limited, Kanagawa, Japan; and Ga
  • Yashiro H; Cardiovascular and Metabolic Drug Discovery Unit (Y.O.T., J.S., M.W.), Drug Metabolism & Pharmacokinetics Research Laboratories (S.I., K.A.), Biomolecular Research Laboratories (M.S.), and Drug Safety Research Laboratories (H.Yasu.), Takeda Pharmaceutical Company Limited, Kanagawa, Japan; and Ga
J Pharmacol Exp Ther ; 379(3): 280-289, 2021 11.
Article in En | MEDLINE | ID: mdl-34535562
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetyl-CoA Carboxylase / Enzyme Inhibitors / Non-alcoholic Fatty Liver Disease / Liver Cirrhosis Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Pharmacol Exp Ther Year: 2021 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetyl-CoA Carboxylase / Enzyme Inhibitors / Non-alcoholic Fatty Liver Disease / Liver Cirrhosis Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Pharmacol Exp Ther Year: 2021 Document type: Article Country of publication: