Rodent models of metabolic disorders: considerations for use in studies of neonatal programming.
Br J Nutr
; 128(5): 802-827, 2022 09 14.
Article
in En
| MEDLINE
| ID: mdl-34551828
ABSTRACT
Epidemiologically, metabolic disorders have garnered much attention, perhaps due to the predominance of obesity. The early postnatal life represents a critical period for programming multifactorial metabolic disorders of adult life. Though altricial rodents are prime subjects for investigating neonatal programming, there is still no sufficiently generalised literature on their usage and methodology. This review focuses on establishing five approach-based models of neonatal rodents adopted for studying metabolic phenotypes. Here, some modelled interventions that currently exist to avoid or prevent metabolic disorders are also highlighted. We also bring forth recommendations, guidelines and considerations to aid research on neonatal programming. It is hoped that this provides a background to researchers focused on the aetiology, mechanisms, prevention and treatment of metabolic disorders.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rodentia
/
Metabolic Diseases
Type of study:
Guideline
Limits:
Animals
Language:
En
Journal:
Br J Nutr
Year:
2022
Document type:
Article
Affiliation country: