Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer.

Carter, David M; Specker, Edgar; Malecki, Piotr H; Przygodda, Jessica; Dudaniec, Krystyna; Weiss, Manfred S; Heinemann, Udo; Nazaré, Marc; Gohlke, Ulrich

Carter, David M; Specker, Edgar; Malecki, Piotr H; Przygodda, Jessica; Dudaniec, Krystyna; Weiss, Manfred S; Heinemann, Udo; Nazaré, Marc; Gohlke, Ulrich.

Affiliation

Carter DM; Max Delbrück Center for Molecular Medicine in the Helmholtz Gemeinschaft (MDC), Berlin 13125 Germany.
Specker E; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin 13125, Germany.
Malecki PH; Max Delbrück Center for Molecular Medicine in the Helmholtz Gemeinschaft (MDC), Berlin 13125 Germany.
Przygodda J; Helmholtz-Zentrum Berlin (HZB) Macromolecular Crystallography, Berlin 14109, Germany.
Dudaniec K; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin 13125, Germany.
Weiss MS; Max Delbrück Center for Molecular Medicine in the Helmholtz Gemeinschaft (MDC), Berlin 13125 Germany.
Heinemann U; Helmholtz-Zentrum Berlin (HZB) Macromolecular Crystallography, Berlin 14109, Germany.
Nazaré M; Max Delbrück Center for Molecular Medicine in the Helmholtz Gemeinschaft (MDC), Berlin 13125 Germany.
Gohlke U; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin 13125, Germany.

J Med Chem ; 64(19): 14266-14282, 2021 10 14.

Article in En | MEDLINE | ID: mdl-34555281

Subject(s)

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Jumonji Domain-Containing Histone Demethylases Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2021 Document type: Article Country of publication:

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google