Arithmetic Word-Problem Solving as Cognitive Marker of Progression in Pre-Manifest and Manifest Huntington's Disease.
J Huntingtons Dis
; 10(4): 459-468, 2021.
Article
in En
| MEDLINE
| ID: mdl-34602494
BACKGROUND: Arithmetic word-problem solving depends on the interaction of several cognitive processes that may be affected early in the disease in gene-mutation carriers for Huntington's disease (HD). OBJECTIVE: Our goal was to examine the pattern of performance of arithmetic tasks in premanifest and manifest HD, and to examine correlations between arithmetic task performance and other neuropsychological tasks. METHODS: We collected data from a multicenter cohort of 165 HD gene-mutation carriers. The sample consisted of 31 premanifest participants: 16 far-from (>12 years estimated time to diagnosis; preHD-A) and 15 close-to (≤12 years estimated time to diagnosis; preHD-B), 134 symptomatic patients (early-mild HD), and 37 healthy controls (HC). We compared performance between groups and explored the associations between arithmetic word-problem solving and neuropsychological and clinical variables. RESULTS: Total arithmetic word-problem solving scores were lower in preHD-B patients than in preHD-A (pâ<â0.05) patients and HC (pâ<â0.01). Early-mild HD patients had lower scores than preHD patients (pâ<â0.001) and HC (pâ<â0.001). Compared to HC, preHD and early-mild HD participants made more errors as trial complexity increased. Moreover, arithmetic word-problem solving scores were significantly associated with measures of global cognition (pâ<â0.001), frontal-executive functions (pâ<â0.001), attention (pâ<â0.001) visual working memory (pâ<â0.001), mental rotation (pâ<â0.001), and confrontation naming (pâ<â0.05). CONCLUSION: Arithmetic word-problem solving is affected early in the course of HD and is related to deficient processes in frontal-executive and mentalizing-related processes.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Huntington Disease
Type of study:
Clinical_trials
Limits:
Humans
Language:
En
Journal:
J Huntingtons Dis
Year:
2021
Document type:
Article
Affiliation country:
Country of publication: