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Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease.
Scortecci, Jessica Fernandes; Molday, Laurie L; Curtis, Susan B; Garces, Fabian A; Panwar, Pankaj; Van Petegem, Filip; Molday, Robert S.
Affiliation
  • Scortecci JF; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.
  • Molday LL; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.
  • Curtis SB; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.
  • Garces FA; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.
  • Panwar P; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.
  • Van Petegem F; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.
  • Molday RS; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada. molday@mail.ubc.ca.
Nat Commun ; 12(1): 5902, 2021 10 08.
Article in En | MEDLINE | ID: mdl-34625547
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: ATP-Binding Cassette Transporters / Cryoelectron Microscopy / Stargardt Disease Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: ATP-Binding Cassette Transporters / Cryoelectron Microscopy / Stargardt Disease Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: Country of publication: