Cell membrane skeletal protein 4.1R participates in entry of Zika virus into cells.
Virus Res
; 306: 198593, 2021 12.
Article
in En
| MEDLINE
| ID: mdl-34637814
ABSTRACT
Zika virus (ZIKV) is a typical mosquito-borne flavivirus known to cause severe fetal microcephaly and adult Guillain-Barré syndrome. Currently, there are no specific drugs or licensed vaccines available for ZIKV infection, and further research is required to identify host cell proteins involved in the virus's life cycle. Viruses are known to use host cell membrane skeletal proteins, such as actin and spectrin, to complete cell entry, transportation, and release. Here, based on immunoprecipitation, the Axl and ZIKV envelope (E) protein were shown to interact with the cell membrane skeleton protein 4.1R. Furthermore, deletion of 4.1R significantly reduced virus titer and viral protein synthesis. Our study showed that 4.1R is an important host cell protein during ZIKV infection and may be involved in the process of viral entry into host cells.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Zika Virus
/
Zika Virus Infection
Limits:
Animals
Language:
En
Journal:
Virus Res
Journal subject:
VIROLOGIA
Year:
2021
Document type:
Article