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The antimetastatic breast cancer activity of the viral protein-derived peptide vCPP2319 as revealed by cellular biomechanics.
Oliveira, Filipa D; Cavaco, Marco; Figueira, Tiago N; Valle, Javier; Neves, Vera; Andreu, David; Gaspar, Diana; Castanho, Miguel A R B.
Affiliation
  • Oliveira FD; Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Portugal.
  • Cavaco M; Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Portugal.
  • Figueira TN; Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Portugal.
  • Valle J; Department of Experimental and Health Sciences, Barcelona Biomedical Research Park, Pompeu Fabra University, Barcelona, Spain.
  • Neves V; Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Portugal.
  • Andreu D; Department of Experimental and Health Sciences, Barcelona Biomedical Research Park, Pompeu Fabra University, Barcelona, Spain.
  • Gaspar D; Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Portugal.
  • Castanho MARB; Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Portugal.
FEBS J ; 289(6): 1603-1624, 2022 03.
Article in En | MEDLINE | ID: mdl-34679257
The incidence of metastatic breast cancer (MBC) is increasing and the therapeutic arsenal available to fight it is insufficient. Brain metastases, in particular, represent a major challenge for chemotherapy as the impermeable nature of the blood-brain barrier (BBB) prevents most drugs from targeting cells in the brain. For their ability to transpose biological membranes and transport a broad spectrum of bioactive cargoes, cell-penetrating peptides (CPPs) have been hailed as ideal candidates to deliver drugs across biological barriers. A more ambitious approach is to have the CPP as a drug itself, capable of both killing cancer cells and interacting with the blood/brain interface, therefore blocking the onset of brain metastases. vCPP2319, a viral protein-derived CPP, has both properties as it: (a) is selective toward human breast cancer cells (MDA-MB-231) and increases cell stiffness compared to breast epithelial cells (MCF 10A) hindering the progression of metastases; and (b) adsorbs at the surface of human brain endothelial cells potentially counteracting metastatic cells from reaching the brain. Overall, the results reveal the selective anticancer activity of the peptide vCPP2319, which is also able to reside at the blood-brain interface, therefore counteracting brain penetration by metastatic cancer cells.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Breast Neoplasms / Cell-Penetrating Peptides Limits: Female / Humans Language: En Journal: FEBS J Journal subject: BIOQUIMICA Year: 2022 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Breast Neoplasms / Cell-Penetrating Peptides Limits: Female / Humans Language: En Journal: FEBS J Journal subject: BIOQUIMICA Year: 2022 Document type: Article Affiliation country: Country of publication: