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A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eµ-TCL1 mice through the JNK/STAT4/p66Shc axis.
Vanni, Francesca; Lopresti, Ludovica; Zurli, Vanessa; Kabanova, Anna; Cattaneo, Francesca; Sicuranza, Anna; Gozzetti, Alessandro; Gemma, Sandra; Zisterer, Daniela M; Bocchia, Monica; Campiani, Giuseppe; Baldari, Cosima T; Butini, Stefania; Ulivieri, Cristina.
Affiliation
  • Vanni F; Department of Life Sciences, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy; Istituto Toscano Tumori, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy.
  • Lopresti L; Department of Life Sciences, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy; Istituto Toscano Tumori, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy.
  • Zurli V; Department of Life Sciences, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy; Istituto Toscano Tumori, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy.
  • Kabanova A; Department of Life Sciences, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy; Istituto Toscano Tumori, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy.
  • Cattaneo F; Department of Life Sciences, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy; Istituto Toscano Tumori, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy.
  • Sicuranza A; Hematology Unit, Azienda Ospedaliera Universitaria Senese, University of Siena, V.le Mario Bracci, 16, 53100 Siena, Italy.
  • Gozzetti A; Hematology Unit, Azienda Ospedaliera Universitaria Senese, University of Siena, V.le Mario Bracci, 16, 53100 Siena, Italy.
  • Gemma S; Istituto Toscano Tumori, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, Via Aldo Moro, 2, 53100 Siena, Italy.
  • Zisterer DM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin 2, Ireland.
  • Bocchia M; Hematology Unit, Azienda Ospedaliera Universitaria Senese, University of Siena, V.le Mario Bracci, 16, 53100 Siena, Italy.
  • Campiani G; Istituto Toscano Tumori, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, Via Aldo Moro, 2, 53100 Siena, Italy.
  • Baldari CT; Department of Life Sciences, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy; Istituto Toscano Tumori, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy.
  • Butini S; Istituto Toscano Tumori, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, Via Aldo Moro, 2, 53100 Siena, Italy. Electronic address: butini3@unisi.i.
  • Ulivieri C; Department of Life Sciences, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy; Istituto Toscano Tumori, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy. Electronic address: cristina.ulivieri@unisi.it.
Pharmacol Res ; 174: 105965, 2021 12.
Article in En | MEDLINE | ID: mdl-34732370
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxazepines / Leukemia, Lymphocytic, Chronic, B-Cell / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Pharmacol Res Journal subject: FARMACOLOGIA Year: 2021 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxazepines / Leukemia, Lymphocytic, Chronic, B-Cell / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Pharmacol Res Journal subject: FARMACOLOGIA Year: 2021 Document type: Article Affiliation country: Country of publication: