Polarimetric visualization of healthy brain fiber tracts under adverse conditions: ex vivo studies.
Biomed Opt Express
; 12(10): 6674-6685, 2021 Oct 01.
Article
in En
| MEDLINE
| ID: mdl-34745764
ABSTRACT
We suggest using the wide-field imaging Mueller polarimetry to contrast optically anisotropic fiber tracts of healthy brain white matter for the detection of brain tumor borders during neurosurgery. Our prior studies demonstrate that this polarimetric imaging modality detects correctly the in-plane orientation of brain white matter fiber tracts of a flat formalin-fixed thick brain specimen in reflection geometry [IEEE Trans. Med. Imaging39, 4376 (2020)10.1109/TMI.2020.3018439]. Here we present the results of ex vivo polarimetric studies of large cross-sections of fresh calf brain in reflection geometry with a special focus on the impact of the adverse measurement conditions (e.g. complex surface topography, presence of blood, etc.) on the quality of polarimetric images and the detection performance of white matter fiber tracts and their in-plane orientation.
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01-internacional
Database:
MEDLINE
Language:
En
Journal:
Biomed Opt Express
Year:
2021
Document type:
Article
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