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Anosognosia in Amnestic Mild Cognitive Impairment Is Related to Diminished Hippocampal Volume Comparable to Alzheimer's Disease Dementia: Preliminary MRI Findings.
Flores-Vázquez, Juan Francisco; Ramírez-García, Gabriel; Marrufo-Meléndez, Oscar René; Alcalá-Lozano, Ruth; Lietz, Morten Peter; Rodríguez-Agudelo, Yaneth; Acosta-Castillo, Gilberto Isaac; Renken, Remco J; Aleman, Andre; Enriquez-Geppert, Stefanie; Sosa-Ortiz, Ana Luisa.
Affiliation
  • Flores-Vázquez JF; Programa de Maestría y Doctorado en Ciencias Médicas, Odontológicas y de la Salud, Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Ramírez-García G; Laboratorio de Demencias, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico.
  • Marrufo-Meléndez OR; Department of Clinical and Developmental Neuropsychology, University of Groningen, Groningen, Netherlands.
  • Alcalá-Lozano R; Section of Cognitive Neuropsychiatry, Department of Biomedical Sciences of Cells and Systems, University of Groningen, Groningen, Netherlands.
  • Lietz MP; Laboratorio de Neuropsicología, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Rodríguez-Agudelo Y; Unidad de Neuroimagen, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico.
  • Acosta-Castillo GI; Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico.
  • Renken RJ; Department of Clinical and Developmental Neuropsychology, University of Groningen, Groningen, Netherlands.
  • Aleman A; Section of Cognitive Neuropsychiatry, Department of Biomedical Sciences of Cells and Systems, University of Groningen, Groningen, Netherlands.
  • Enriquez-Geppert S; Departamento de Neuropsicología, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico.
  • Sosa-Ortiz AL; Programa de Maestría y Doctorado en Ciencias Médicas, Odontológicas y de la Salud, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Front Aging Neurosci ; 13: 739422, 2021.
Article in En | MEDLINE | ID: mdl-34776927
Although the presence of anosognosia in amnestic mild cognitive impairment (aMCI) may be predictive of conversion to Alzheimer's disease (AD), little is known about its neural correlates in AD and aMCI. Four different groups were compared using volumetric and diffusion magnetic resonance imaging metrics in regions of interest (hippocampus and cingulum cortex gray matter, cingulum bundle white matter): aMCI subjects with anosognosia (n = 6), aMCI subjects without anosognosia (n = 12), AD subjects with anosognosia (n = 6), and AD subjects without anosognosia (n = 9). aMCI subjects with anosognosia displayed a significantly lower gray matter density (GMD) in the bilateral hippocampus than aMCI subjects without anosognosia, which was accounted for by bilateral hippocampal differences. Furthermore, we identified that the mean hippocampal gray matter density of aMCI subjects with anosognosia was not statistically different than that of AD subjects. The groups of aMCI and AD subjects with anosognosia also displayed a lower GMD in the bilateral cingulum cortex compared to subjects without anosognosia, but these differences were not statistically significant. No statistically significant differences were found in the fractional anisotropy or mean diffusivity of the hippocampus or cingulum between subjects with and without anosognosia in aMCI or AD groups. While these findings are derived from a small population of subjects and are in need of replication, they suggest that anosognosia in aMCI might be a useful clinical marker to suspect brain changes associated with AD neuropathology.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies / Prognostic_studies Language: En Journal: Front Aging Neurosci Year: 2021 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies / Prognostic_studies Language: En Journal: Front Aging Neurosci Year: 2021 Document type: Article Affiliation country: Country of publication: