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Gelatinase-sensitive nanoparticles loaded with photosensitizer and STAT3 inhibitor for cancer photothermal therapy and immunotherapy.
Bu, Lin-Lin; Wang, Han-Qi; Pan, Yuanwei; Chen, Lei; Wu, Hao; Wu, Xianjia; Zhao, Chenchen; Rao, Lang; Liu, Bing; Sun, Zhi-Jun.
Affiliation
  • Bu LL; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China. lin-lin.bu@whu.edu.cn.
  • Wang HQ; Department of Oral & Maxillofacial-Head & Neck Oncology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China. lin-lin.bu@whu.edu.cn.
  • Pan Y; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.
  • Chen L; Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory, Shenzhen, 518132, China.
  • Wu H; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.
  • Wu X; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.
  • Zhao C; Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory, Shenzhen, 518132, China.
  • Rao L; Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory, Shenzhen, 518132, China.
  • Liu B; Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory, Shenzhen, 518132, China. lrao@szbl.ac.cn.
  • Sun ZJ; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China. liubing9909@whu.edu.cn.
J Nanobiotechnology ; 19(1): 379, 2021 Nov 21.
Article in En | MEDLINE | ID: mdl-34802438
Matrix metalloproteinase (MMP) 2 and 9 are the family members of proteases normally up-regulated in tumor to enhance the invasion and metastatic of tumor cells, and are associated with poor outcome of head and neck squamous cell carcinomas (HNSCCs). In the present work, MMPs-degradable gelatin nanoparticles (GNPs) are simultaneously loaded with photosensitizer indocyanine green (ICG) along with signal transducer activator of transcription 3 (STAT3) inhibitor NSC74859 (NSC, N) for efficient photothermal therapy (PTT) and immunotherapy of HNSCCs. In the tumor tissue, Gel-N-ICG nanoparticle was degraded and encapsulated ICG and NSC were effectively released. Under near-infrared (NIR) irradiation, the released ICG nanoparticles enabled effective photothermal destruction of tumors, and the STAT3 inhibitor NSC elicited potent antitumor immunity for enhanced cancer therapy. Based on two HNSCC mouse models, we demonstrated that Gel-N-ICG significantly delayed tumor growth without any appreciable body weight loss. Taken together, the strategy reported here may contribute that the stimuli-responsive proteases triggered nanoplatform could reduce tumor size more effectively in complex tumor microenvironment (TME) through combination of PTT and immunotherapy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Photosensitizing Agents / Gelatinases / Protein Inhibitors of Activated STAT / Nanoparticles Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: J Nanobiotechnology Year: 2021 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Photosensitizing Agents / Gelatinases / Protein Inhibitors of Activated STAT / Nanoparticles Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: J Nanobiotechnology Year: 2021 Document type: Article Affiliation country: Country of publication: