Identifying tumorigenic non-coding mutations through altered cis-regulation.
STAR Protoc
; 2(4): 100934, 2021 12 17.
Article
in En
| MEDLINE
| ID: mdl-34816127
ABSTRACT
Identification of non-coding mutations driving tumorigenesis requires alternative approaches to coding mutations. Enriched associations between mutated regulatory elements and altered cis-regulation in tumors are a promising approach to stratify candidate non-coding driver mutations. Here we provide a bioinformatics pipeline to mine data from the Cancer Genomic Commons (GDC) for such associations. The pipeline integrates RNA and whole-genome sequencing with genotyping data to reveal putative non-coding driver mutations by cancer type. For complete information on the generation and use of this protocol, please refer to Cheng et al. (2021).
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Regulatory Sequences, Nucleic Acid
/
Computational Biology
/
Carcinogenesis
/
Mutation
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
STAR Protoc
Year:
2021
Document type:
Article
Affiliation country: