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Suppression of Kv3.3 channels by antisense oligonucleotides reverses biochemical effects and motor impairment in spinocerebellar ataxia type 13 mice.
Zhang, Yalan; Quraishi, Imran H; McClure, Heather; Williams, Luis A; Cheng, YungChih; Kale, Siddharth; Dempsey, Graham T; Agrawal, Sudhir; Gerber, David J; McManus, Owen B; Kaczmarek, Leonard K.
Affiliation
  • Zhang Y; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA.
  • Quraishi IH; Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.
  • McClure H; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA.
  • Williams LA; Q-State Biosciences, Cambridge, Massachusetts, USA.
  • Cheng Y; Q-State Biosciences, Cambridge, Massachusetts, USA.
  • Kale S; Q-State Biosciences, Cambridge, Massachusetts, USA.
  • Dempsey GT; Q-State Biosciences, Cambridge, Massachusetts, USA.
  • Agrawal S; ARNAY Sciences, Shrewsbury, Massachusetts, USA.
  • Gerber DJ; Q-State Biosciences, Cambridge, Massachusetts, USA.
  • McManus OB; Q-State Biosciences, Cambridge, Massachusetts, USA.
  • Kaczmarek LK; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA.
FASEB J ; 35(12): e22053, 2021 12.
Article in En | MEDLINE | ID: mdl-34820911
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides, Antisense / Protein Serine-Threonine Kinases / Spinocerebellar Ataxias / Shaw Potassium Channels / Motor Disorders / Mutation Type of study: Etiology_studies Limits: Animals Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2021 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides, Antisense / Protein Serine-Threonine Kinases / Spinocerebellar Ataxias / Shaw Potassium Channels / Motor Disorders / Mutation Type of study: Etiology_studies Limits: Animals Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2021 Document type: Article Affiliation country: Country of publication: