Omega-3 index is directly associated with a healthy red blood cell distribution width.
Prostaglandins Leukot Essent Fatty Acids
; 176: 102376, 2022 01.
Article
in En
| MEDLINE
| ID: mdl-34839221
ABSTRACT
Low red blood cell (RBC) membrane content of EPA and DHA, i.e., the omega-3 index (O3I), and elevated RBC distribution width (RDW) are risk factors for all-cause mortality. O3I and RDW are related with membrane fluidity and deformability. Our objective was to determine if there is a relationship between O3I and RDW in healthy adults. Subjects without inflammation or anemia, and with values for O3I, RDW, high-sensitivity C-reactive protein (CRP), body mass index (BMI), age and sex were identified (n = 25,485) from a clinical laboratory dataset of > 45,000 individuals. RDW was inversely associated with O3I in both sexes before and after (both p < 0.00001) adjusting models for sex, age, BMI and CRP. Stratification by sex revealed a sex-O3I interaction with the RDW-O3I slope (p < 0.00066) being especially steep in females with O3I ≤ 5.6%. In healthy adults of both sexes, the data suggested that an O3I of > 5.6% may help maintain normal RBC structural and functional integrity.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Eicosapentaenoic Acid
/
Docosahexaenoic Acids
/
Health Status
/
Cell Size
/
Erythrocyte Membrane
/
Erythrocytes
Type of study:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspects:
Determinantes_sociais_saude
/
Patient_preference
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Prostaglandins Leukot Essent Fatty Acids
Journal subject:
ENDOCRINOLOGIA
Year:
2022
Document type:
Article