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Inhibition of cytoplasmic EZH2 induces antitumor activity through stabilization of the DLC1 tumor suppressor protein.
Tripathi, Brajendra K; Anderman, Meghan F; Bhargava, Disha; Boccuzzi, Luciarita; Qian, Xiaolan; Wang, Dunrui; Durkin, Marian E; Papageorge, Alex G; de Miguel, Fernando J; Politi, Katerina; Walters, Kylie J; Doroshow, James H; Lowy, Douglas R.
Affiliation
  • Tripathi BK; Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. tripathib@mail.nih.gov.
  • Anderman MF; Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
  • Bhargava D; Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
  • Boccuzzi L; Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
  • Qian X; Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
  • Wang D; Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
  • Durkin ME; Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
  • Papageorge AG; Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
  • de Miguel FJ; Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
  • Politi K; Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
  • Walters KJ; Departments of Pathology and Internal Medicine (Section of Medical Oncology), Yale School of Medicine, New Haven, CT, USA.
  • Doroshow JH; Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.
  • Lowy DR; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Nat Commun ; 12(1): 6941, 2021 12 03.
Article in En | MEDLINE | ID: mdl-34862367
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: GTPase-Activating Proteins / Tumor Suppressor Proteins / Enhancer of Zeste Homolog 2 Protein / Lung Neoplasms / Antineoplastic Agents Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: GTPase-Activating Proteins / Tumor Suppressor Proteins / Enhancer of Zeste Homolog 2 Protein / Lung Neoplasms / Antineoplastic Agents Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: Country of publication: