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Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice.
Kenjo, Eriya; Hozumi, Hiroyuki; Makita, Yukimasa; Iwabuchi, Kumiko A; Fujimoto, Naoko; Matsumoto, Satoru; Kimura, Maya; Amano, Yuichiro; Ifuku, Masataka; Naoe, Youichi; Inukai, Naoto; Hotta, Akitsu.
Affiliation
  • Kenjo E; T-CiRA Discovery, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan.
  • Hozumi H; Takeda-CiRA Joint Program, Fujisawa, Kanagawa, Japan.
  • Makita Y; T-CiRA Discovery, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan.
  • Iwabuchi KA; Takeda-CiRA Joint Program, Fujisawa, Kanagawa, Japan.
  • Fujimoto N; T-CiRA Discovery, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan.
  • Matsumoto S; Takeda-CiRA Joint Program, Fujisawa, Kanagawa, Japan.
  • Kimura M; Takeda-CiRA Joint Program, Fujisawa, Kanagawa, Japan.
  • Amano Y; Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
  • Ifuku M; Takeda-CiRA Joint Program, Fujisawa, Kanagawa, Japan.
  • Naoe Y; Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
  • Inukai N; Takeda-CiRA Joint Program, Fujisawa, Kanagawa, Japan.
  • Hotta A; Drug Product Development, Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan.
Nat Commun ; 12(1): 7101, 2021 12 08.
Article in En | MEDLINE | ID: mdl-34880218
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Messenger / Muscle, Skeletal / CRISPR-Cas Systems / Gene Editing Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Messenger / Muscle, Skeletal / CRISPR-Cas Systems / Gene Editing Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: