Radical-anion coupling through reagent design: hydroxylation of aryl halides.
Chem Sci
; 12(43): 14641-14646, 2021 Nov 10.
Article
in En
| MEDLINE
| ID: mdl-34881017
ABSTRACT
The design and development of an oxime-based hydroxylation reagent, which can chemoselectively convert aryl halides (X = F, Cl, Br, I) into phenols under operationally simple, transition-metal-free conditions is described. Key to the success of this approach was the identification of a reducing oxime anion which can interact and couple with open-shell aryl radicals. Experimental and computational studies support the proposed radical-nucleophilic substitution chain mechanism.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Chem Sci
Year:
2021
Document type:
Article