Alanine transaminase is predominantly increased in the active phase of anti-HMGCR myopathy.
Neuromuscul Disord
; 32(1): 25-32, 2022 01.
Article
in En
| MEDLINE
| ID: mdl-34916121
ABSTRACT
Autoantibodies against 3hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and the signal recognition particle (SRP) are representative antibodies causing immune-mediated necrotizing myopathies (IMNM), called as anti-HMGCR and anti-SRP myopathies, respectively. Here, we analyzed the differences in routine blood test results between 56 anti-HMGCR and 77 anti-SRP myopathy patients. A higher alanine transaminase (ALT) level and a lower aspartate transaminase (AST)/ALT ratio were observed in anti-HMGCR myopathy patients [ALT, 265.7⯱â¯213.3â¯U/L (mean ± standard deviation); AST/ALT ratio, 0.88⯱â¯0.32] than in anti-SRP-myopathy patients (ALT, 179.3⯱â¯111.2â¯U/L, p < 0.05; AST/ALT ratio, 1.28⯱â¯0.40, p < 0.01). In the active phase, anti-HMGCR myopathy often showed ALT predominance, whereas anti-SRP myopathy often showed AST predominance. In addition, there were differences in erythrocyte sedimentation rate (ESR), total cholesterol (TChol) level, and high-density lipoprotein (HDL) level between anti-HMGCR and anti-SRP myopathies (ESR HMGCR, 24.4⯱â¯20.8â¯mm/1â¯h; SRP, 35.7⯱â¯26.7â¯mm/1â¯h, pâ¯=â¯0.0334; TChol HMGCR, 226.7⯱â¯36.6â¯mg/dL; SRP, 207.6⯱â¯40.8â¯mg/dL, pâ¯=â¯0.0163; HDL HMGCR, 58.4⯱â¯13.9â¯mg/dL; SRP, 46.2⯱â¯17.3â¯mg/dL, p < 0.01). Additional studies on the differences in routine blood test results may further reveal the pathomechanisms of IMNM.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Alanine Transaminase
/
Hydroxymethylglutaryl CoA Reductases
/
Muscular Diseases
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Neuromuscul Disord
Journal subject:
NEUROLOGIA
Year:
2022
Document type:
Article