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Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity.
Porniece Kumar, Marta; Cremer, Anna Lena; Klemm, Paul; Steuernagel, Lukas; Sundaram, Sivaraj; Jais, Alexander; Hausen, A Christine; Tao, Jenkang; Secher, Anna; Pedersen, Thomas Åskov; Schwaninger, Markus; Wunderlich, F Thomas; Lowell, Bradford B; Backes, Heiko; Brüning, Jens C.
Affiliation
  • Porniece Kumar M; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany.
  • Cremer AL; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany.
  • Klemm P; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany.
  • Steuernagel L; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany.
  • Sundaram S; Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.
  • Jais A; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany.
  • Hausen AC; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.
  • Tao J; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany.
  • Secher A; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Pedersen TÅ; Program in Neuroscience, Harvard Medical School, Boston, MA, USA.
  • Schwaninger M; Global Drug Discovery, Novo Nordisk A/S, Måløv, Denmark.
  • Wunderlich FT; Global Drug Discovery, Novo Nordisk A/S, Måløv, Denmark.
  • Lowell BB; Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.
  • Backes H; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany.
  • Brüning JC; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Nat Metab ; 3(12): 1662-1679, 2021 12.
Article in En | MEDLINE | ID: mdl-34931084
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Agouti-Related Protein / Ependymoglial Cells / Hypothalamus / Insulin / Neurons Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nat Metab Year: 2021 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Agouti-Related Protein / Ependymoglial Cells / Hypothalamus / Insulin / Neurons Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nat Metab Year: 2021 Document type: Article Affiliation country: