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Evidence of SARS-CoV-2-Specific T-Cell-Mediated Myocarditis in a MIS-A Case.
Vannella, Kevin M; Oguz, Cihan; Stein, Sydney R; Pittaluga, Stefania; Dikoglu, Esra; Kanwal, Arjun; Ramelli, Sabrina C; Briese, Thomas; Su, Ling; Wu, Xiaolin; Ramos-Benitez, Marcos J; Perez-Valencia, Luis J; Babyak, Ashley; Cha, Nu Ri; Chung, Joon-Yong; Ylaya, Kris; Madathil, Ronson J; Saharia, Kapil K; Scalea, Thomas M; Tran, Quincy K; Herr, Daniel L; Kleiner, David E; Hewitt, Stephen M; Notarangelo, Luigi D; Grazioli, Alison; Chertow, Daniel S.
Affiliation
  • Vannella KM; Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
  • Oguz C; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
  • Stein SR; National Institute of Allergy and Infectious Diseases Collaborative Bioinformatics Resource, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, United States.
  • Pittaluga S; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, United States.
  • Dikoglu E; Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
  • Kanwal A; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
  • Ramelli SC; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
  • Briese T; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
  • Su L; Division of Cardiology, Westchester Medical Center, Valhalla, NY, United States.
  • Wu X; Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
  • Ramos-Benitez MJ; Center for Infection and Immunity, Columbia University Mailman School of Public Health, New York, NY, United States.
  • Perez-Valencia LJ; Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, United States.
  • Babyak A; Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, United States.
  • Cha NR; Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
  • Chung JY; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
  • Ylaya K; Postdoctoral Research Associate Training Program, National Institute of General Medical Sciences, National Institutes of Health, Bethesda, MD, United States.
  • Madathil RJ; Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
  • Saharia KK; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
  • Scalea TM; Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
  • Tran QK; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
  • Herr DL; Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
  • Kleiner DE; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
  • Hewitt SM; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
  • Notarangelo LD; Department of Surgery, Division of Cardiac Surgery, University of Maryland School of Medicine, Baltimore, MD, United States.
  • Grazioli A; Department of Medicine, Division of Infectious Disease, University of Maryland School of Medicine, Baltimore, MD, United States.
  • Chertow DS; Department of Surgery, Program in Trauma, R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, United States.
Front Immunol ; 12: 779026, 2021.
Article in En | MEDLINE | ID: mdl-34956207
A 26-year-old otherwise healthy man died of fulminant myocarditis. Nasopharyngeal specimens collected premortem tested negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Histopathological evaluation of the heart showed myocardial necrosis surrounded by cytotoxic T-cells and tissue-repair macrophages. Myocardial T-cell receptor (TCR) sequencing revealed hyper-dominant clones with highly similar sequences to TCRs that are specific for SARS-CoV-2 epitopes. SARS-CoV-2 RNA was detected in the gut, supporting a diagnosis of multisystem inflammatory syndrome in adults (MIS-A). Molecular targets of MIS-associated inflammation are not known. Our data indicate that SARS-CoV-2 antigens selected high-frequency T-cell clones that mediated fatal myocarditis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Systemic Inflammatory Response Syndrome / COVID-19 / Myocarditis Limits: Adult / Humans / Male Language: En Journal: Front Immunol Year: 2021 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Systemic Inflammatory Response Syndrome / COVID-19 / Myocarditis Limits: Adult / Humans / Male Language: En Journal: Front Immunol Year: 2021 Document type: Article Affiliation country: Country of publication: