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Deleterious Genetic Variation Across the NOD Signaling Pathway Is Associated With Reduced NFKB Signaling Transcription and Upregulation of Alternative Inflammatory Transcripts in Pediatric Inflammatory Bowel Disease.
Ashton, James J; Boukas, Konstantinos; Stafford, Imogen S; Cheng, Guo; Haggarty, Rachel; Coelho, Tracy A F; Batra, Akshay; Afzal, Nadeem A; Williams, Anthony P; Polak, Marta E; Beattie, R Mark; Ennis, Sarah.
Affiliation
  • Ashton JJ; Department of Human Genetics and Genomic Medicine, University of Southampton, Southampton, United Kingdom.
  • Boukas K; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, United Kingdom.
  • Stafford IS; Wessex Investigational Sciences Hub laboratory (WISH lab), University of Southampton, Faculty of Medicine, Southampton, United Kingdom.
  • Cheng G; Department of Human Genetics and Genomic Medicine, University of Southampton, Southampton, United Kingdom.
  • Haggarty R; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom.
  • Coelho TAF; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, United Kingdomand.
  • Batra A; Department of Human Genetics and Genomic Medicine, University of Southampton, Southampton, United Kingdom.
  • Afzal NA; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, United Kingdomand.
  • Williams AP; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, United Kingdomand.
  • Polak ME; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, United Kingdom.
  • Beattie RM; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, United Kingdom.
  • Ennis S; Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, United Kingdom.
Inflamm Bowel Dis ; 28(6): 912-922, 2022 06 03.
Article in En | MEDLINE | ID: mdl-34978330
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammatory Bowel Diseases / Nod2 Signaling Adaptor Protein Type of study: Prognostic_studies / Risk_factors_studies Limits: Child / Humans Language: En Journal: Inflamm Bowel Dis Journal subject: GASTROENTEROLOGIA Year: 2022 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammatory Bowel Diseases / Nod2 Signaling Adaptor Protein Type of study: Prognostic_studies / Risk_factors_studies Limits: Child / Humans Language: En Journal: Inflamm Bowel Dis Journal subject: GASTROENTEROLOGIA Year: 2022 Document type: Article Affiliation country: Country of publication: