Targeting PGM3 as a Novel Therapeutic Strategy in <i>KRAS/LKB1</i> Co-Mutant Lung Cancer.

Lee, Hyunmin; Cai, Feng; Kelekar, Neil; Velupally, Nipun K; Kim, Jiyeon

Targeting PGM3 as a Novel Therapeutic Strategy in KRAS/LKB1 Co-Mutant Lung Cancer.

Lee, Hyunmin; Cai, Feng; Kelekar, Neil; Velupally, Nipun K; Kim, Jiyeon.

Affiliation

Lee H; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA.
Cai F; Children's Medical Center Research Institute, UT-Southwestern Medical Center, Dallas, TX 75390, USA.
Kelekar N; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA.
Velupally NK; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA.
Kim J; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA.

Cells ; 11(1)2022 01 05.

Article in En | MEDLINE | ID: mdl-35011738

Subject(s)
Key words

KRAS and LKB1 co-mutations; O-GlcNAcylation; cancer metabolism; glycosylation; metabolic vulnerability; non-small cell lung cancer; the hexosamine biosynthesis pathway

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphoglucomutase / Proto-Oncogene Proteins p21(ras) / Molecular Targeted Therapy / AMP-Activated Protein Kinase Kinases / Lung Neoplasms Limits: Animals / Humans Language: En Journal: Cells Year: 2022 Document type: Article Affiliation country:

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