APOBEC3C S188I Polymorphism Enhances Context-Specific Editing of Hepatitis B Virus Genome.
J Infect Dis
; 226(5): 891-895, 2022 09 13.
Article
in En
| MEDLINE
| ID: mdl-35022749
Single-nucleotide polymorphism in APOBEC3C (resulting in a serine to isoleucine in position 188) is present in approximately 10% of African populations and greatly enhances restriction against human immunodeficiency virus-1 and simian immunodeficiency virus by improving dimerization and DNA processivity of the enzyme. In this study, we demonstrated in culture and in infected patients that hepatitis B virus (HBV) could be edited by APOBEC3CS188I. Using next-generation sequencing, we demonstrated that APOBEC3CS188I led to enhanced editing activity in 5'TpCpAâ5'TpTpA context. This constitutes a new hallmark of this enzyme, which could be used to determine its impact on HBV or nuclear DNA.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hepatitis B virus
/
Genome, Viral
/
Cytidine Deaminase
Limits:
Humans
Language:
En
Journal:
J Infect Dis
Year:
2022
Document type:
Article
Affiliation country:
Country of publication: