Your browser doesn't support javascript.
loading
Natural and human-driven selection of a single non-coding body size variant in ancient and modern canids.
Plassais, Jocelyn; vonHoldt, Bridgett M; Parker, Heidi G; Carmagnini, Alberto; Dubos, Nicolas; Papa, Ilenia; Bevant, Kevin; Derrien, Thomas; Hennelly, Lauren M; Whitaker, D Thad; Harris, Alex C; Hogan, Andrew N; Huson, Heather J; Zaibert, Victor F; Linderholm, Anna; Haile, James; Fest, Thierry; Habib, Bilal; Sacks, Benjamin N; Benecke, Norbert; Outram, Alan K; Sablin, Mikhail V; Germonpré, Mietje; Larson, Greger; Frantz, Laurent; Ostrander, Elaine A.
Affiliation
  • Plassais J; Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: jocelyn.plassais@univ-rennes1.fr.
  • vonHoldt BM; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.
  • Parker HG; Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Carmagnini A; School of Biological and Chemical Sciences, Queen Mary University of London, London, UK.
  • Dubos N; INRAE UMR TETIS, Maison de la Télédétection, Montpellier, France.
  • Papa I; INSERM, UMR1236-MICMAC, University of Rennes 1, Hematology Department CHU Rennes, Rennes, France.
  • Bevant K; INSERM, UMR1242-COSS, University of Rennes 1, Centre de lutte contre le Cancer Eugène Marquis, CHU Rennes, Rennes, France.
  • Derrien T; CNRS, IGDR-UMR6290, University of Rennes 1, Rennes, France.
  • Hennelly LM; Mammalian Ecology and Conservation Unit, Veterinary Genetics Laboratory, Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
  • Whitaker DT; Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Harris AC; Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Hogan AN; Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Huson HJ; Department of Animal Science, Cornell University, Ithaca, NY, USA.
  • Zaibert VF; Institute of Archaeology and Steppe Civilizations, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
  • Linderholm A; Centre for Paleogenomics, Department of Geological Sciences, Stockholm University, Stockholm, Sweden; The Paleogenomics and Bio-Archaeology Research Network, Research Laboratory for Archaeology and History of Art, University of Oxford, Oxford, UK.
  • Haile J; The Paleogenomics and Bio-Archaeology Research Network, Research Laboratory for Archaeology and History of Art, University of Oxford, Oxford, UK.
  • Fest T; INSERM, UMR1236-MICMAC, University of Rennes 1, Hematology Department CHU Rennes, Rennes, France.
  • Habib B; Department of Animal Ecology and Conservation Biology, Wildlife Institute of India, Dehradun, India.
  • Sacks BN; Mammalian Ecology and Conservation Unit, Veterinary Genetics Laboratory, Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
  • Benecke N; Scientific Department of the Head Office, German Archaeological Institute, Berlin, Germany.
  • Outram AK; Department of Archaeology, University of Exeter, Laver Building, Exeter, UK.
  • Sablin MV; Zoological Institute of the Russian Academy of Sciences, Saint Petersburg, Russian Federation.
  • Germonpré M; Royal Belgian Institute of Natural Sciences, Brussels, Belgium.
  • Larson G; The Paleogenomics and Bio-Archaeology Research Network, Research Laboratory for Archaeology and History of Art, University of Oxford, Oxford, UK.
  • Frantz L; School of Biological and Chemical Sciences, Queen Mary University of London, London, UK; Paleogenetics Group, Department of Veterinary Sciences, Ludwig Maximilian University, Munich, Germany.
  • Ostrander EA; Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: eostrand@mail.nih.gov.
Curr Biol ; 32(4): 889-897.e9, 2022 02 28.
Article in En | MEDLINE | ID: mdl-35090588
Domestic dogs (Canis lupus familiaris) are the most variable-sized mammalian species on Earth, displaying a 40-fold size difference between breeds.1 Although dogs of variable size are found in the archeological record,2-4 the most dramatic shifts in body size are the result of selection over the last two centuries, as dog breeders selected and propagated phenotypic extremes within closed breeding populations.5 Analyses of over 200 domestic breeds have identified approximately 20 body size genes regulating insulin processing, fatty acid metabolism, TGFß signaling, and skeletal formation.6-10 Of these, insulin-like growth factor 1 (IGF1) predominates, controlling approximately 15% of body size variation between breeds.8 The identification of a functional mutation associated with IGF1 has thus far proven elusive.6,10,11 Here, to identify and elucidate the role of an ancestral IGF1 allele in the propagation of modern canids, we analyzed 1,431 genome sequences from 13 species, including both ancient and modern canids, thus allowing us to define the evolutionary history of both ancestral and derived alleles at this locus. We identified a single variant in an antisense long non-coding RNA (IGF1-AS) that interacts with the IGF1 gene, creating a duplex. While the derived mutation predominates in both modern gray wolves and large domestic breeds, the ancestral allele, which predisposes to small size, was common in small-sized breeds and smaller wild canids. Our analyses demonstrate that this major regulator of canid body size nearly vanished in Pleistocene wolves, before its recent resurgence resulting from human-imposed selection for small-sized breed dogs.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Wolves / Canidae Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Curr Biol Journal subject: BIOLOGIA Year: 2022 Document type: Article Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Wolves / Canidae Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Curr Biol Journal subject: BIOLOGIA Year: 2022 Document type: Article Country of publication: