Lignans and sesquiterpenes from Schisandra tomentella A. C. Smith.
Fitoterapia
; 158: 105142, 2022 Apr.
Article
in En
| MEDLINE
| ID: mdl-35124161
ABSTRACT
This is the first phytochemical investigation of Schisandra tomentella A. C. Smith. 11 lignans and 8 sesquiterpenoids, were isolated from the stems of S. tomentella, including two undescribed lignans, tomentaschinins A-B (1-2), and two new sesquiterpenoids, tomentaschinnes A-B (3-4). Their structures were elucidated based on the interpretation of their spectroscopic data. Cytotoxicity and MDR reversal effect of these compounds were screened on multidrug resistance cancer cell line MCF-7/ADR, and results showed gomisin M2 (7) could promote the efficacy of adriamycin against MCF-7/ADR.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sesquiterpenes
/
Lignans
/
Schisandra
Language:
En
Journal:
Fitoterapia
Year:
2022
Document type:
Article