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Improvement of the pharmacokinetics and antifibrotic effects of nintedanib by intrapulmonary administration of a nintedanib-hydroxypropyl-γ-cyclodextrin inclusion complex in mice with bleomycin-induced pulmonary fibrosis.
Togami, Kohei; Ogasawara, Arisa; Irie, Sayo; Iwata, Kenji; Yamaguchi, Kotaro; Tada, Hitoshi; Chono, Sumio.
Affiliation
  • Togami K; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, 7-Jo 15-4-1 Maeda, Teine, Sapporo, Hokkaido 006-8585, Japan; Creation Research Institute of Life Science in KITA-no-DAICHI, 7-Jo 15-4-1 Maeda, Teine, Sapporo, Hokkaido 006-8585, Japan. Electronic address
  • Ogasawara A; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, 7-Jo 15-4-1 Maeda, Teine, Sapporo, Hokkaido 006-8585, Japan.
  • Irie S; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, 7-Jo 15-4-1 Maeda, Teine, Sapporo, Hokkaido 006-8585, Japan.
  • Iwata K; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, 7-Jo 15-4-1 Maeda, Teine, Sapporo, Hokkaido 006-8585, Japan.
  • Yamaguchi K; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, 7-Jo 15-4-1 Maeda, Teine, Sapporo, Hokkaido 006-8585, Japan.
  • Tada H; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, 7-Jo 15-4-1 Maeda, Teine, Sapporo, Hokkaido 006-8585, Japan.
  • Chono S; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, 7-Jo 15-4-1 Maeda, Teine, Sapporo, Hokkaido 006-8585, Japan; Creation Research Institute of Life Science in KITA-no-DAICHI, 7-Jo 15-4-1 Maeda, Teine, Sapporo, Hokkaido 006-8585, Japan.
Eur J Pharm Biopharm ; 172: 203-212, 2022 Mar.
Article in En | MEDLINE | ID: mdl-35183716
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bleomycin / Idiopathic Pulmonary Fibrosis Limits: Animals Language: En Journal: Eur J Pharm Biopharm Journal subject: FARMACIA / FARMACOLOGIA Year: 2022 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bleomycin / Idiopathic Pulmonary Fibrosis Limits: Animals Language: En Journal: Eur J Pharm Biopharm Journal subject: FARMACIA / FARMACOLOGIA Year: 2022 Document type: Article Country of publication: