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The future of circulating tumor DNA as a biomarker in HPV related oropharyngeal squamous cell carcinoma.
Haring, Catherine T; Dermody, Sarah M; Yalamanchi, Pratyusha; Kang, Stephen Y; Old, Matthew O; Chad Brenner, J; Spector, Matthew E; Rocco, James W.
Affiliation
  • Haring CT; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, OH, United States. Electronic address: Catherine.haring@osumc.edu.
  • Dermody SM; Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, MI, United States.
  • Yalamanchi P; Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, MI, United States.
  • Kang SY; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, OH, United States.
  • Old MO; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, OH, United States.
  • Chad Brenner J; Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, MI, United States.
  • Spector ME; Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, MI, United States.
  • Rocco JW; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, OH, United States.
Oral Oncol ; 126: 105776, 2022 03.
Article in En | MEDLINE | ID: mdl-35183912
ABSTRACT
Human papillomavirus (HPV) related oropharyngeal squamous cell carcinoma (OPSCC) is associated with improved outcomes compared to non-virally mediated disease. Clinical trials are actively investigating de-escalation strategies to maintain excellent survival outcomes while minimizing toxicity. Delivery of effective precision medicine-based therapeutic approaches are strengthened by the identification of biomarkers to predict treatment response. Plasma circulating tumor (ct) DNA is the most studied liquid biomarker in head and neck cancer and has shown great promise in the ability to determine treatment response and monitor for disease recurrence. In this review, we examine the emerging evidence for ctDNA as a biomarker in HPV related OPSCC and discuss opportunities for future investigation and integration into clinical practice.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Squamous Cell / Oropharyngeal Neoplasms / Papillomavirus Infections / Alphapapillomavirus / Circulating Tumor DNA / Head and Neck Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: Oral Oncol Journal subject: NEOPLASIAS Year: 2022 Document type: Article
Fulltext
Add to My VHL
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Squamous Cell / Oropharyngeal Neoplasms / Papillomavirus Infections / Alphapapillomavirus / Circulating Tumor DNA / Head and Neck Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: Oral Oncol Journal subject: NEOPLASIAS Year: 2022 Document type: Article