Photoinduced Cascade C-N/CâO Bond Formation from Bromodifluoroalkyl Reagents, Amines, and H2O via a Triple-Cleavage Process.
Org Lett
; 24(8): 1668-1672, 2022 03 04.
Article
in En
| MEDLINE
| ID: mdl-35191309
ABSTRACT
A green, sustainable, and straightforward method for the synthesis of unsymmetrical oxalamides via photoinduced C-N/CâO bond formation of bromodifluoroacetamide, amine, and H2O through a triple-cleavage process has been developed. In addition, this approach also provides access to the known bioactive compounds, and a feasible reaction mechanism is proposed. Moreover, the advantages of this transformation, including mild reaction conditions, a broad substrate scope, and operational simplicity, make this protocol attractive for further applications.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2022
Document type:
Article