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XRCC1 counteracts poly(ADP ribose)polymerase (PARP) poisons, olaparib and talazoparib, and a clinical alkylating agent, temozolomide, by promoting the removal of trapped PARP1 from broken DNA.
Hirota, Kouji; Ooka, Masato; Shimizu, Naoto; Yamada, Kousei; Tsuda, Masataka; Ibrahim, Mahmoud Abdelghany; Yamada, Shintaro; Sasanuma, Hiroyuki; Masutani, Mitsuko; Takeda, Shunichi.
Affiliation
  • Hirota K; Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Ooka M; Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Tokyo, Japan.
  • Shimizu N; Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Tokyo, Japan.
  • Yamada K; Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
  • Tsuda M; Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Ibrahim MA; Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Yamada S; Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Sasanuma H; Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Hiroshima, Japan.
  • Masutani M; Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Takeda S; Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Genes Cells ; 27(5): 331-344, 2022 May.
Article in En | MEDLINE | ID: mdl-35194903

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Poisons / Poly(ADP-ribose) Polymerases Language: En Journal: Genes Cells Journal subject: BIOLOGIA MOLECULAR Year: 2022 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Poisons / Poly(ADP-ribose) Polymerases Language: En Journal: Genes Cells Journal subject: BIOLOGIA MOLECULAR Year: 2022 Document type: Article Affiliation country: Country of publication: