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Polymethyl Methacrylate-Based Smart Microfluidic Point-of-Care Testing of Prothrombin Time and International Normalized Ratio through Optical Detection.
Abdulhay, Enas W; Khnouf, Ruba E; Karain, Yahia M; Al Omari, Taqwa K; Ebeid, Nourshan M; Al Muhtaseb, Tamara H; Arunkumar, N; Thilagaraj, M; Ramirez-Gonzalez, Gustavo.
Affiliation
  • Abdulhay EW; Biomedical Engineering Department, Jordan University of Science and Technology, Irbid 22110, Jordan.
  • Khnouf RE; Biomedical Engineering Department, Jordan University of Science and Technology, Irbid 22110, Jordan.
  • Karain YM; Biomedical Engineering Department, Jordan University of Science and Technology, Irbid 22110, Jordan.
  • Al Omari TK; Biomedical Engineering Department, Jordan University of Science and Technology, Irbid 22110, Jordan.
  • Ebeid NM; Biomedical Engineering Department, Jordan University of Science and Technology, Irbid 22110, Jordan.
  • Al Muhtaseb TH; Biomedical Engineering Department, Jordan University of Science and Technology, Irbid 22110, Jordan.
  • Arunkumar N; Department of Biomedical Engineering, Rathinam Technical Campus, Coimbatore, India.
  • Thilagaraj M; Department of Electronics and Instrumentation Engineering, Karpagam College of Engineering, Coimbatore, India.
  • Ramirez-Gonzalez G; Departamento de Telematica, Universidad del Cauca, Colombia.
Comput Math Methods Med ; 2022: 5975228, 2022.
Article in En | MEDLINE | ID: mdl-35222684
The mechanical heart valve is a crucial solution for many patients. However, it cannot function on the state of blood as human tissue valves. Thus, people with mechanical valves are put under anticoagulant therapy. A good measurement of the state of blood and how long it takes blood to form clots is the prothrombin time (PT); moreover, it is an indicator of how well the anticoagulant therapy is, and of whether the response of the patient to the drug is as needed. For a more specific standardized measurement of coagulation time, an international normalized ratio (INR) is established. Clinical testing of INR and PT is relatively easy. However, it requires the patient to visit the clinic for evaluation purposes. Many techniques are therefore being developed to provide PT and INR self-testing devices. Unfortunately, those solutions are either inaccurate, complex, or expensive. The present work approaches the design of an anticoagulation self-monitoring device that is easy to use, accurate, and relatively inexpensive. Hence, a two-channel polymethyl methacrylate-based microfluidic point-of-care (POC) smart device has been developed. The Arduino based lab-on-a-chip device applies optical properties to a small amount of blood. The achieved accuracy is 96.7%.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prothrombin Time / International Normalized Ratio / Lab-On-A-Chip Devices / Point-of-Care Testing Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Comput Math Methods Med Journal subject: INFORMATICA MEDICA Year: 2022 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prothrombin Time / International Normalized Ratio / Lab-On-A-Chip Devices / Point-of-Care Testing Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Comput Math Methods Med Journal subject: INFORMATICA MEDICA Year: 2022 Document type: Article Affiliation country: Country of publication: