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Chemical Composition Analysis, Cytotoxic, Antimicrobial and Antioxidant Activities of Physalis angulata L.: A Comparative Study of Leaves and Fruit.
Ramakrishna Pillai, Jayachithra; Wali, Adil Farooq; Menezes, Godfred Antony; Rehman, Muneeb U; Wani, Tanveer A; Arafah, Azher; Zargar, Seema; Mir, Tahir Maqbool.
Affiliation
  • Ramakrishna Pillai J; Department of Pharmaceutical Chemistry, RAK College of Pharmaceutical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah 11172, United Arab Emirates.
  • Wali AF; Department of Pharmaceutical Chemistry, RAK College of Pharmaceutical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah 11172, United Arab Emirates.
  • Menezes GA; Department of Microbiology, RAKCOMS, RAK Medical and Health Sciences University, Ras Al Khaimah 11172, United Arab Emirates.
  • Rehman MU; Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
  • Wani TA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
  • Arafah A; Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
  • Zargar S; Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
  • Mir TM; National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Mississippi, MS 38677, USA.
Molecules ; 27(5)2022 Feb 22.
Article in En | MEDLINE | ID: mdl-35268579
ABSTRACT
Physalis angulata L. belongs to the family Solanaceae and is distributed throughout the tropical and subtropical regions. Physalis angulata leaf and fruit extracts were assessed for in vitro anticancer, antioxidant activity, and total phenolic and flavonoid content. The GC-MS technique investigated the chemical composition and structure of bioactive chemicals reported in extracts. The anticancer activity results revealed a decrease in the percentage of anticancer cells' viability in a concentration- and time-dependent way. We also noticed morphological alterations in the cells, which we believe are related to Physalis angulata extracts. Under light microscopy, we observed that as the concentration of ethanolic extract (fruit and leaves) treated HeLa cells increased, the number of cells began to decrease.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Physalis Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2022 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Physalis Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2022 Document type: Article Affiliation country: