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Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses.
Milligan, Jacob C; Davis, Carl W; Yu, Xiaoying; Ilinykh, Philipp A; Huang, Kai; Halfmann, Peter J; Cross, Robert W; Borisevich, Viktoriya; Agans, Krystle N; Geisbert, Joan B; Chennareddy, Chakravarthy; Goff, Arthur J; Piper, Ashley E; Hui, Sean; Shaffer, Kelly C L; Buck, Tierra; Heinrich, Megan L; Branco, Luis M; Crozier, Ian; Holbrook, Michael R; Kuhn, Jens H; Kawaoka, Yoshihiro; Glass, Pamela J; Bukreyev, Alexander; Geisbert, Thomas W; Worwa, Gabriella; Ahmed, Rafi; Saphire, Erica Ollmann.
Affiliation
  • Milligan JC; Center for Infectious Disease and Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
  • Davis CW; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.
  • Yu X; Center for Infectious Disease and Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Ilinykh PA; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX, 77550, USA.
  • Huang K; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX, 77550, USA.
  • Halfmann PJ; Division of Pathobiological Sciences, University of Wisconsin, Madison, WI 53706, USA.
  • Cross RW; Galveston National Laboratory, Galveston, TX, 77550, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Borisevich V; Galveston National Laboratory, Galveston, TX, 77550, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Agans KN; Galveston National Laboratory, Galveston, TX, 77550, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Geisbert JB; Galveston National Laboratory, Galveston, TX, 77550, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Chennareddy C; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.
  • Goff AJ; Virology Division, United States Army Research Institute for Infectious Disease, Fort Detrick, Frederick, MD 21702, USA.
  • Piper AE; Virology Division, United States Army Research Institute for Infectious Disease, Fort Detrick, Frederick, MD 21702, USA.
  • Hui S; Center for Infectious Disease and Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
  • Shaffer KCL; Center for Infectious Disease and Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
  • Buck T; Center for Infectious Disease and Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
  • Heinrich ML; Zalgen Labs, Germantown, MD 20876, USA.
  • Branco LM; Zalgen Labs, Germantown, MD 20876, USA.
  • Crozier I; Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
  • Holbrook MR; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA.
  • Kuhn JH; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA.
  • Kawaoka Y; Division of Pathobiological Sciences, University of Wisconsin, Madison, WI 53706, USA; Department of Microbiology and Immunology, Division of Virology, Institute of Medical Science, Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science,
  • Glass PJ; Virology Division, United States Army Research Institute for Infectious Disease, Fort Detrick, Frederick, MD 21702, USA.
  • Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX, 77550, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Geisbert TW; Galveston National Laboratory, Galveston, TX, 77550, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Worwa G; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA. Electronic address: gabriella.worwa@nih.gov.
  • Ahmed R; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA. Electronic address: rahmed@emory.edu.
  • Saphire EO; Center for Infectious Disease and Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: erica@lji.org.
Cell ; 185(6): 995-1007.e18, 2022 03 17.
Article in En | MEDLINE | ID: mdl-35303429
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hemorrhagic Fever, Ebola / Ebolavirus / Antibodies, Neutralizing / Antibodies, Viral Limits: Animals Language: En Journal: Cell Year: 2022 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hemorrhagic Fever, Ebola / Ebolavirus / Antibodies, Neutralizing / Antibodies, Viral Limits: Animals Language: En Journal: Cell Year: 2022 Document type: Article Affiliation country: Country of publication: