Your browser doesn't support javascript.
loading
Overcoming Multidrug Resistance of Antibiotics via Nanodelivery Systems.
Imran, Mohammad; Jha, Saurav Kumar; Hasan, Nazeer; Insaf, Areeba; Shrestha, Jitendra; Shrestha, Jesus; Devkota, Hari Prasad; Khan, Salman; Panth, Nisha; Warkiani, Majid Ebrahimi; Dua, Kamal; Hansbro, Philip M; Paudel, Keshav Raj; Mohammed, Yousuf.
Affiliation
  • Imran M; Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
  • Jha SK; Department of Biomedicine, Health and Life Convergence Sciences, Mokpo National University, Jeonnam 58554, Korea.
  • Hasan N; Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
  • Insaf A; Department of Pharmacognosy and Phytochemistry, Delhi Pharmaceutical Sciences and Research University, New Delhi 110017, India.
  • Shrestha J; College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam 58554, Korea.
  • Shrestha J; School of Biomedical Engineering, University of Technology Sydney, Sydney 2007, Australia.
  • Devkota HP; Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo ku, Kumamoto 862-0973, Japan.
  • Khan S; Department of Public Health, School of Allied Health Sciences, Noida International University, Greater Noida 203201, India.
  • Panth N; Centre of Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney 2007, Australia.
  • Warkiani ME; School of Biomedical Engineering, University of Technology Sydney, Sydney 2007, Australia.
  • Dua K; Institute for Biomedical Materials and Devices, Faculty of Science, University of Technology Sydney, Sydney 2007, Australia.
  • Hansbro PM; Centre of Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney 2007, Australia.
  • Paudel KR; Discipline of Pharmacy, Graduate School of Health, University of Technology, Sydney 2007, Australia.
  • Mohammed Y; Faculty of Health, Australian Research Centre in Complementary & Integrative Medicine, University of Technology Sydney, Ultimo 2007, Australia.
Pharmaceutics ; 14(3)2022 Mar 08.
Article in En | MEDLINE | ID: mdl-35335962
Antibiotic resistance has become a threat to microbial therapies nowadays. The conventional approaches possess several limitations to combat microbial infections. Therefore, to overcome such complications, novel drug delivery systems have gained pharmaceutical scientists' interest. Significant findings have validated the effectiveness of novel drug delivery systems such as polymeric nanoparticles, liposomes, metallic nanoparticles, dendrimers, and lipid-based nanoparticles against severe microbial infections and combating antimicrobial resistance. This review article comprises the specific mechanism of antibiotic resistance development in bacteria. In addition, the manuscript incorporated the advanced nanotechnological approaches with their mechanisms, including interaction with the bacterial cell wall, inhibition of biofilm formations, activation of innate and adaptive host immune response, generation of reactive oxygen species, and induction of intracellular effect to fight against antibiotic resistance. A section of this article demonstrated the findings related to the development of delivery systems. Lastly, the role of microfluidics in fighting antimicrobial resistance has been discussed. Overall, this review article is an amalgamation of various strategies to study the role of novel approaches and their mechanism to fight against the resistance developed to the antimicrobial therapies.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Pharmaceutics Year: 2022 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Pharmaceutics Year: 2022 Document type: Article Affiliation country: Country of publication: