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The association between inflammatory biomarkers and statin use among patients with head and neck squamous cell carcinoma.
Getz, Kayla R; Bellile, Emily; Zarins, Katie R; Chinn, Steven B; Taylor, Jeremy M G; Rozek, Laura S; Wolf, Gregory T; Mondul, Alison M.
Affiliation
  • Getz KR; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
  • Bellile E; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
  • Zarins KR; Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
  • Chinn SB; Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan, USA.
  • Taylor JMG; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
  • Rozek LS; Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
  • Wolf GT; Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan, USA.
  • Mondul AM; Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan, USA.
Head Neck ; 44(6): 1393-1403, 2022 06.
Article in En | MEDLINE | ID: mdl-35338544
ABSTRACT

BACKGROUND:

Tumor-infiltrating lymphocytes (TILs) and cytokines are associated with prognosis among patients with head and neck squamous cell carcinoma (HNSCC). Statins (cholesterol-lowering drugs) may improve HNSCC prognosis, particularly in human papillomavirus (HPV)-positive cases, but the mechanism remains unclear.

METHODS:

Statin use was collected from medical records for HNSCC cases (2008-2014). TILs were counted in tumor tissue, and a total weighted score (TILws) was created. Cytokines were measured in blood. The associations between statins and biomarkers were estimated using logistic (biomarker categories linear regression models (log-transformed continuous biomarkers) adjusted for age, smoking, and comorbidities.

RESULTS:

We observed a positive association between statins and TILs among HPV-positive patients (TILws odds ratio [OR] = 2.80; 95% CI = 1.03-7.61), but no association among HPV-negative patients. We observed no association between statins and cytokines.

CONCLUSIONS:

Statins may influence TILs in HPV-positive patients. This may be the mechanism through which they improve prognosis in HPV-positive HNSCC patients.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hydroxymethylglutaryl-CoA Reductase Inhibitors / Papillomavirus Infections / Head and Neck Neoplasms Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Head Neck Journal subject: NEOPLASIAS Year: 2022 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hydroxymethylglutaryl-CoA Reductase Inhibitors / Papillomavirus Infections / Head and Neck Neoplasms Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Head Neck Journal subject: NEOPLASIAS Year: 2022 Document type: Article Affiliation country: