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Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy.
Campiani, Giuseppe; Khan, Tuhina; Ulivieri, Cristina; Staiano, Leopoldo; Papulino, Chiara; Magnano, Stefania; Nathwani, Seema; Ramunno, Anna; Lucena-Agell, Daniel; Relitti, Nicola; Federico, Stefano; Pozzetti, Luca; Carullo, Gabriele; Casagni, Alice; Brogi, Simone; Vanni, Francesca; Galatello, Paola; Ghanim, Magda; McCabe, Niamh; Lamponi, Stefania; Valoti, Massimo; Ibrahim, Ola; O'Sullivan, Jeffrey; Turkington, Richard; Kelly, Vincent P; VanWemmel, Ruben; Díaz, J Fernando; Gemma, Sandra; Zisterer, Daniela; Altucci, Lucia; De Matteis, Antonella; Butini, Stefania; Benedetti, Rosaria.
Affiliation
  • Campiani G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy. Electronic address: giuseppe.campiani@unisi.it.
  • Khan T; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.
  • Ulivieri C; Department of Life Sciences, University of Siena, via Aldo Moro 2, 53100, Siena, Italy; Istituto Toscano Tumori, University of Siena, via Aldo Moro 2, I, 53100, Siena, Italy.
  • Staiano L; Cell Biology and Disease Mechanisms, Telethon Institute of Genetics and Medicine, Via Campi Flegrei, 34, 80078, Pozzuoli, Naples, Italy; Institute for Genetic and Biomedical Research, National Research Council (CNR), via Fratelli Cervi 93, 20054, Segrate, Milan, Italy.
  • Papulino C; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Vico L, De Crecchio 7, 80138, Naples, IT, Italy.
  • Magnano S; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160, Pearse Street, Dublin 2, Ireland.
  • Nathwani S; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160, Pearse Street, Dublin 2, Ireland.
  • Ramunno A; Department of Pharmacy, University of Salerno, via G. Paolo II 132, 84084, Fisciano (SA), Italy.
  • Lucena-Agell D; Centro de Investigaciones Biologicas Margarita Salas, Consejo Superior de Investigaciones Cientificas, Ramiro de Maeztu 9, 28040, Madrid, Spain.
  • Relitti N; IRBM Science Park, Via Pontina km 30, 600, 00071, Pomezia, Rome, Italy.
  • Federico S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.
  • Pozzetti L; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.
  • Carullo G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.
  • Casagni A; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.
  • Brogi S; Department of Pharmacy, University of Pisa, 56126, Pisa, Italy.
  • Vanni F; Department of Life Sciences, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.
  • Galatello P; Department of Pharmacy, University of Salerno, via G. Paolo II 132, 84084, Fisciano (SA), Italy.
  • Ghanim M; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160, Pearse Street, Dublin 2, Ireland.
  • McCabe N; School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Health Sciences Building, BT9 7BL, Belfast, United Kingdom.
  • Lamponi S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.
  • Valoti M; Department of Life Sciences, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.
  • Ibrahim O; School of Dental Science, Trinity College Dublin, Lincoln Place, Dublin 2, Ireland.
  • O'Sullivan J; School of Dental Science, Trinity College Dublin, Lincoln Place, Dublin 2, Ireland.
  • Turkington R; School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Health Sciences Building, BT9 7BL, Belfast, United Kingdom.
  • Kelly VP; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160, Pearse Street, Dublin 2, Ireland.
  • VanWemmel R; Centro de Investigaciones Biologicas Margarita Salas, Consejo Superior de Investigaciones Cientificas, Ramiro de Maeztu 9, 28040, Madrid, Spain.
  • Díaz JF; Centro de Investigaciones Biologicas Margarita Salas, Consejo Superior de Investigaciones Cientificas, Ramiro de Maeztu 9, 28040, Madrid, Spain.
  • Gemma S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.
  • Zisterer D; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160, Pearse Street, Dublin 2, Ireland.
  • Altucci L; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Vico L, De Crecchio 7, 80138, Naples, IT, Italy; Biogem Institute of Molecular Biology and Genetics, Via Camporeale, 83031, Ariano Irpino, Italy.
  • De Matteis A; Cell Biology and Disease Mechanisms, Telethon Institute of Genetics and Medicine, Via Campi Flegrei, 34, 80078, Pozzuoli, Naples, Italy.
  • Butini S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy; Istituto Toscano Tumori, University of Siena, via Aldo Moro 2, I, 53100, Siena, Italy. Electronic address: butini3@unisi.it.
  • Benedetti R; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Vico L, De Crecchio 7, 80138, Naples, IT, Italy.
Eur J Med Chem ; 235: 114274, 2022 May 05.
Article in En | MEDLINE | ID: mdl-35344902
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mouth Neoplasms / Carcinoma, Squamous Cell / Antineoplastic Agents Limits: Humans Language: En Journal: Eur J Med Chem Year: 2022 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mouth Neoplasms / Carcinoma, Squamous Cell / Antineoplastic Agents Limits: Humans Language: En Journal: Eur J Med Chem Year: 2022 Document type: Article