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RELATIONSHIP BETWEEN CHOROIDAL FINDINGS AND GROWTH FACTORS, CYTOKINES, AND OTHER INFLAMMATORY MEDIATORS AFTER INTRAVITREAL RANIBIZUMAB INJECTION IN PATIENTS WITH MACULAR EDEMA SECONDARY TO BRANCH RETINAL VEIN OCCLUSION.
Noma, Hidetaka; Yasuda, Kanako; Mimura, Tatsuya; Shimura, Masahiko.
Affiliation
  • Noma H; Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan ; and.
  • Yasuda K; Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan ; and.
  • Mimura T; Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan .
  • Shimura M; Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan ; and.
Retina ; 42(4): 744-751, 2022 04 01.
Article in En | MEDLINE | ID: mdl-35350049
ABSTRACT

PURPOSE:

To examine possible associations between subfoveal choroidal thickness (SCT), choroidal blood flow, aqueous flare value, and aqueous humor levels of multiple growth factors, cytokines, and other inflammatory mediators in patients with branch retinal vein occlusion and macular edema who received antivascular endothelial growth factor (anti-VEGF) therapy.

METHODS:

We recruited 65 patients with macular edema due to branch retinal vein occlusion who received intravitreal ranibizumab injection and measured aqueous levels of eight factors by the suspension array method. Furthermore, we evaluated choroidal blood flows by laser speckle flowgraphy and quantified them as the mean blur rate and measured aqueous flare values using a laser flare meter and SCT and central macular thickness by optical coherence tomography.

RESULTS:

At 1 month after intravitreal ranibizumab injection, central macular thickness was significantly improved and SCT, choroidal mean blur rate, and aqueous flare value were significantly decreased. SCT was significantly correlated with vascular endothelial growth factor and placental growth factor, and the change in both SCT and central macular thickness was significantly correlated with the change in aqueous flare value. However, only SCT was significantly negatively correlated with the aqueous flare value.

CONCLUSION:

Growth factors seem to play a role in SCT. In macular edema with branch retinal vein occlusion, antivascular endothelial growth factor agents may decrease SCT by reducing inflammation.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinal Vein Occlusion / Macular Edema / Ranibizumab Type of study: Diagnostic_studies / Etiology_studies Limits: Humans Language: En Journal: Retina Year: 2022 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinal Vein Occlusion / Macular Edema / Ranibizumab Type of study: Diagnostic_studies / Etiology_studies Limits: Humans Language: En Journal: Retina Year: 2022 Document type: Article