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Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor.
Miller, Duncan C; Reuillon, Tristan; Molyneux, Lauren; Blackburn, Timothy; Cook, Simon J; Edwards, Noel; Endicott, Jane A; Golding, Bernard T; Griffin, Roger J; Hardcastle, Ian; Harnor, Suzannah J; Heptinstall, Amy; Lochhead, Pamela; Martin, Mathew P; Martin, Nick C; Myers, Stephanie; Newell, David R; Noble, Richard A; Phillips, Nicole; Rigoreau, Laurent; Thomas, Huw; Tucker, Julie A; Wang, Lan-Zhen; Waring, Michael J; Wong, Ai-Ching; Wedge, Stephen R; Noble, Martin E M; Cano, Celine.
Affiliation
  • Miller DC; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.
  • Reuillon T; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.
  • Molyneux L; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.
  • Blackburn T; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.
  • Cook SJ; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K.
  • Edwards N; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
  • Endicott JA; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
  • Golding BT; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.
  • Griffin RJ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.
  • Hardcastle I; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.
  • Harnor SJ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.
  • Heptinstall A; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.
  • Lochhead P; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K.
  • Martin MP; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
  • Martin NC; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.
  • Myers S; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.
  • Newell DR; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
  • Noble RA; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
  • Phillips N; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
  • Rigoreau L; Cancer Research UK Therapeutic Discovery Laboratories, Jonas Webb Building, Babraham Campus, Babraham, Cambridgeshire CB22 3AT, U.K.
  • Thomas H; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
  • Tucker JA; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
  • Wang LZ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
  • Waring MJ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.
  • Wong AC; Cancer Research UK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, U.K.
  • Wedge SR; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
  • Noble MEM; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
  • Cano C; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.
J Med Chem ; 65(9): 6513-6540, 2022 05 12.
Article in En | MEDLINE | ID: mdl-35468293
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Mitogen-Activated Protein Kinase 7 Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Mitogen-Activated Protein Kinase 7 Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: Country of publication: