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Inflammasome activation in infected macrophages drives COVID-19 pathology.
Sefik, Esen; Qu, Rihao; Junqueira, Caroline; Kaffe, Eleanna; Mirza, Haris; Zhao, Jun; Brewer, J Richard; Han, Ailin; Steach, Holly R; Israelow, Benjamin; Blackburn, Holly N; Velazquez, Sofia E; Chen, Y Grace; Halene, Stephanie; Iwasaki, Akiko; Meffre, Eric; Nussenzweig, Michel; Lieberman, Judy; Wilen, Craig B; Kluger, Yuval; Flavell, Richard A.
Affiliation
  • Sefik E; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
  • Qu R; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
  • Junqueira C; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
  • Kaffe E; Computational Biology and Bioinformatics Program, Yale University, New Haven, CT, USA.
  • Mirza H; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
  • Zhao J; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
  • Brewer JR; Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Brazil.
  • Han A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
  • Steach HR; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
  • Israelow B; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
  • Blackburn HN; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
  • Velazquez SE; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
  • Chen YG; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
  • Halene S; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
  • Iwasaki A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
  • Meffre E; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
  • Nussenzweig M; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
  • Lieberman J; Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.
  • Wilen CB; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
  • Kluger Y; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
  • Flavell RA; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Nature ; 606(7914): 585-593, 2022 06.
Article in En | MEDLINE | ID: mdl-35483404
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammasomes / SARS-CoV-2 / COVID-19 / Macrophages Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nature Year: 2022 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammasomes / SARS-CoV-2 / COVID-19 / Macrophages Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nature Year: 2022 Document type: Article Affiliation country: Country of publication: