Prognostic value of arterial stiffness in menopausal women.
Menopause
; 29(5): 573-579, 2022 05 01.
Article
in En
| MEDLINE
| ID: mdl-35486947
ABSTRACT
OBJECTIVE:
Because menopausal women have an increased cardiovascular risk, risk stratification is very crucial in this population. This study aimed to verify the prognostic value of arterial stiffness in menopausal women.METHODS:
We retrospectively analyzed 2,917 menopausal women (age >55y) without overt cardiovascular disease who underwent brachial-ankle pulse wave velocity measurement. The primary endpoint was a composite of clinical events, including all-cause death, nonfatal myocardial infarction, coronary revascularization, and stroke, hereafter referred to as major adverse cardiovascular events. Propensity score matching and inverse probability-treatment weighting analysis were used to balance differences in baseline participant characteristics.RESULTS:
The mean participant age was 66.8â±â7.7âyears. During a median follow-up period of 4.0 (interquartile range of 1.9-6.3) years, the primary outcome was noted in 56 cases (1.9%). Pulse wave velocity was significantly higher in participants with the primary outcome than in those without (1,947â±â388 vs 1,690â±â348âcm/s; Pâ <â0.001). For every 100âcm/s increase in pulse wave velocity, the hazard ratio for the primary endpoint increased by 1.15 times (95% confidence interval, 1.08-1.22; Pâ <â0.001) in multivariable Cox regression analysis. A pulse wave velocity > 1,613âcm/s was associated with increased risk of the primary endpoint in the same multivariable analysis (hazard ratio, 3.06; 95% confidence interval, 1.40-6.68; Pâ =â0.005). The results were consistent after propensity score matching and inverse probability-treatment weighting analysis.CONCLUSIONS:
Elevated brachial-ankle pulse wave velocity was associated with the occurrence of major adverse cardiovascular events in menopausal women without cardiovascular disease and may represent a useful screening tool.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vascular Stiffness
/
Myocardial Infarction
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Menopause
Journal subject:
GINECOLOGIA
Year:
2022
Document type:
Article