The emerging role of ubiquitin-specific protease 20 in tumorigenesis and cancer therapeutics.
Cell Death Dis
; 13(5): 434, 2022 05 04.
Article
in En
| MEDLINE
| ID: mdl-35508480
ABSTRACT
As a critical member of the ubiquitin-specific proteolytic enzyme family, ubiquitin-specific peptidase 20 (USP20) regulates the stability of proteins via multiple signaling pathways. In addition, USP20 upregulation is associated with various cellular biological processes, such as cell cycle progression, proliferation, migration, and invasion. Emerging studies have revealed the pivotal role of USP20 in the tumorigenesis of various cancer types, such as breast cancer, colon cancer, lung cancer, gastric cancer and adult T cell leukemia. In our review, we highlight the different mechanisms of USP20 in various tumor types and demonstrate that USP20 regulates the stability of multiple proteins. Therefore, regulating the activity of USP20 is a novel tumor treatment. However, the clinical significance of USP20 in cancer treatment merits more evidence. Finally, different prospects exist for the continued research focus of USP20.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Ubiquitin Thiolesterase
Limits:
Female
/
Humans
Language:
En
Journal:
Cell Death Dis
Year:
2022
Document type:
Article