Using MS induced pluripotent stem cells to investigate MS aetiology.
Mult Scler Relat Disord
; 63: 103839, 2022 Jul.
Article
in En
| MEDLINE
| ID: mdl-35523059
ABSTRACT
Multiple sclerosis (MS) is a complex disease, and its pathophysiology impacts the function of immune and central nervous system cell types. Despite extensive investigation into the aetiology of MS, the underlying cause/s remain elusive and consequently, faithful in vitro or in vivo preclinical models of MS do not exist. Advances in human stem cell technologies have enabled the generation of induced pluripotent stem cells (iPSCs) from people with MS. This review summarises the discoveries made using iPSCs derived from people with MS and explores their current and potential application/s in MS research.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Induced Pluripotent Stem Cells
/
Multiple Sclerosis
Type of study:
Etiology_studies
Limits:
Humans
Language:
En
Journal:
Mult Scler Relat Disord
Year:
2022
Document type:
Article