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Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling.
Woodhead, Jeffrey L; Siler, Scott Q; Howell, Brett A; Watkins, Paul B; Conway, Charles.
Affiliation
  • Woodhead JL; DILIsym Services, Inc., A Simulations Plus Company, Research Triangle Park, North Carolina 27706, USA.
  • Siler SQ; DILIsym Services, Inc., A Simulations Plus Company, Research Triangle Park, North Carolina 27706, USA.
  • Howell BA; DILIsym Services, Inc., A Simulations Plus Company, Research Triangle Park, North Carolina 27706, USA.
  • Watkins PB; Institute for Drug Safety Sciences, UNC-Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
  • Conway C; Biohaven Pharmaceuticals, Inc., New Haven, Connecticut 06510, USA.
Toxicol Sci ; 188(1): 108-116, 2022 06 28.
Article in En | MEDLINE | ID: mdl-35556143
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug-Related Side Effects and Adverse Reactions / Chemical and Drug Induced Liver Injury Type of study: Etiology_studies / Prognostic_studies Limits: Humans Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2022 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug-Related Side Effects and Adverse Reactions / Chemical and Drug Induced Liver Injury Type of study: Etiology_studies / Prognostic_studies Limits: Humans Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2022 Document type: Article Affiliation country: Country of publication: