Your browser doesn't support javascript.
loading
Immune response in COVID-19: what is next?
Li, Qing; Wang, Ying; Sun, Qiang; Knopf, Jasmin; Herrmann, Martin; Lin, Liangyu; Jiang, Jingting; Shao, Changshun; Li, Peishan; He, Xiaozhou; Hua, Fei; Niu, Zubiao; Ma, Chaobing; Zhu, Yichao; Ippolito, Giuseppe; Piacentini, Mauro; Estaquier, Jerome; Melino, Sonia; Weiss, Felix Daniel; Andreano, Emanuele; Latz, Eicke; Schultze, Joachim L; Rappuoli, Rino; Mantovani, Alberto; Mak, Tak Wah; Melino, Gerry; Shi, Yufang.
Affiliation
  • Li Q; The Third Affiliated Hospital of Soochow University/The First People's Hospital of Changzhou, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine of Soochow University, Medical College, Suzhou, China.
  • Wang Y; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences/Shanghai Jiao Tong University School of Medicine, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
  • Sun Q; Beijing Institute of Biotechnology, Research Unit of Cell Death Mechanism, Chinese Academy of Medical Sciences, 2021RU008, 20 Dongda Street, 100071, Beijing, China.
  • Knopf J; Deutsches Zentrum für Immuntherapie (DZI), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Herrmann M; Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Lin L; Deutsches Zentrum für Immuntherapie (DZI), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Jiang J; Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Shao C; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences/Shanghai Jiao Tong University School of Medicine, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
  • Li P; The Third Affiliated Hospital of Soochow University/The First People's Hospital of Changzhou, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine of Soochow University, Medical College, Suzhou, China.
  • He X; The Third Affiliated Hospital of Soochow University/The First People's Hospital of Changzhou, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine of Soochow University, Medical College, Suzhou, China.
  • Hua F; The Third Affiliated Hospital of Soochow University/The First People's Hospital of Changzhou, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine of Soochow University, Medical College, Suzhou, China.
  • Niu Z; The Third Affiliated Hospital of Soochow University/The First People's Hospital of Changzhou, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine of Soochow University, Medical College, Suzhou, China.
  • Ma C; The Third Affiliated Hospital of Soochow University/The First People's Hospital of Changzhou, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine of Soochow University, Medical College, Suzhou, China.
  • Zhu Y; Beijing Institute of Biotechnology, Research Unit of Cell Death Mechanism, Chinese Academy of Medical Sciences, 2021RU008, 20 Dongda Street, 100071, Beijing, China.
  • Ippolito G; Beijing Institute of Biotechnology, Research Unit of Cell Death Mechanism, Chinese Academy of Medical Sciences, 2021RU008, 20 Dongda Street, 100071, Beijing, China.
  • Piacentini M; Beijing Institute of Biotechnology, Research Unit of Cell Death Mechanism, Chinese Academy of Medical Sciences, 2021RU008, 20 Dongda Street, 100071, Beijing, China.
  • Estaquier J; Ministry of Health, Rome, Italy.
  • Melino S; Department of Biology, TOR, University of Rome Tor Vergata, 00133, Rome, Italy.
  • Weiss FD; INSERM-U1124, Université Paris, Paris, France.
  • Andreano E; CHU de Québec - Université Laval Research Center, Québec City, QC, Canada.
  • Latz E; Department of Biology, TOR, University of Rome Tor Vergata, 00133, Rome, Italy.
  • Schultze JL; Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
  • Rappuoli R; Research and Development Center, GlaxoSmithKline (GSK), Siena, Italy.
  • Mantovani A; Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
  • Mak TW; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.
  • Melino G; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.
  • Shi Y; Genomics & Immunoregulation, LIMES-Institute, University of Bonn, Bonn, Germany.
Cell Death Differ ; 29(6): 1107-1122, 2022 06.
Article in En | MEDLINE | ID: mdl-35581387
ABSTRACT
The coronavirus disease 2019 (COVID-19) has been a global pandemic for more than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A better understanding of immunity and its regulation in response to SARS-CoV-2 infection is urgently needed. Based on the current literature, we review here the various virus mutations and the evolving disease manifestations along with the alterations of immune responses with specific focuses on the innate immune response, neutrophil extracellular traps, humoral immunity, and cellular immunity. Different types of vaccines were compared and analyzed based on their unique properties to elicit specific immunity. Various therapeutic strategies such as antibody, anti-viral medications and inflammation control were discussed. We predict that with the available and continuously emerging new technologies, more powerful vaccines and administration schedules, more effective medications and better public health measures, the COVID-19 pandemic will be under control in the near future.
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: En Journal: Cell Death Differ Year: 2022 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: En Journal: Cell Death Differ Year: 2022 Document type: Article Affiliation country: