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Long-Term Follow-Up of Refractory Large Macular Hole with Autologous Neurosensory Retinal Free Flap Transplantation.
Lee, Po-Yen; Chang, Yo-Chen; Liu, Pei-Kang; Kao, Tzu-En; Wu, Horng-Jiun; Chen, Kuo-Jen; Wu, Kwou-Yeung; Cheng, Kai-Chun; Wu, Wen-Chuan.
Affiliation
  • Lee PY; Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
  • Chang YC; Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
  • Liu PK; Department of Ophthalmology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung 80145, Taiwan.
  • Kao TE; Department of Ophthalmology, School of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
  • Wu HJ; Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
  • Chen KJ; Department of Ophthalmology, Park One International Hospital, Kaohsiung 81357, Taiwan.
  • Wu KY; Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
  • Cheng KC; Department of Ophthalmology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 81267, Taiwan.
  • Wu WC; Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
J Ophthalmol ; 2022: 1717366, 2022.
Article in En | MEDLINE | ID: mdl-35586596
Purpose: To evaluate the long-term anatomic and functional outcomes of autologous neurosensory retinal free flap transplantation (ART) for patients with refractory large macular hole (MH). Design: Retrospective interventional case series. Methods: We reviewed 9 patients who underwent ART for their refractory large MH. In this extended follow-up study, postoperative assessment including spectral-domain optical coherence tomography and best-corrected visual acuity (BCVA) were recorded at 12, 15, 18, 21, and 24 months after surgery. Results: The macular hole of all patients appeared successfully closed during the whole follow-up period. The mean logMAR BCVA improved from 1.61 ± 0.44 (preoperative) to 0.72 ± 0.30 (12 months after surgery) (p < 0.001). Thereafter, the mean BCVA remained stable at each follow-up. At the mean 16.0 ± 0.8 months postoperatively, inner retinal cystic changes were observed in 4 eyes (44.4%), but these did not significantly affect vision. Conclusion: ART is a good alternative technique for closing large refractory macular holes. Although inner retinal cystic changes were observed in 4 eyes (44.4%), this phenomenon did not significantly affect visual acuity. It provides long-term good anatomical and functional results, especially in cases where insufficient ILM or lens capsule are left.

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Observational_studies / Prognostic_studies Language: En Journal: J Ophthalmol Year: 2022 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Observational_studies / Prognostic_studies Language: En Journal: J Ophthalmol Year: 2022 Document type: Article Affiliation country: Country of publication: