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Alcohol use disorder, psychiatric comorbidities, marriage and divorce in a high-risk sample.
Thomas, Nathaniel S; Kuo, Sally I-Chun; Aliev, Fazil; McCutcheon, Vivia V; Meyers, Jacquelyn M; Chan, Grace; Hesselbrock, Victor; Kamarajan, Chella; Kinreich, Sivan; Kramer, John R; Kuperman, Samuel; Lai, Dongbing; Plawecki, Martin H; Porjesz, Bernice; Schuckit, Marc A; Dick, Danielle M; Bucholz, Kathleen K; Salvatore, Jessica E.
Affiliation
  • Thomas NS; Department of Psychology.
  • Kuo SI; Department of Psychiatry.
  • Aliev F; Department of Psychiatry.
  • McCutcheon VV; Department of Psychiatry.
  • Meyers JM; Department of Psychiatry and Behavioral Sciences.
  • Chan G; Department of Psychiatry.
  • Hesselbrock V; Department of Psychiatry.
  • Kamarajan C; Department of Psychiatry and Behavioral Sciences.
  • Kinreich S; Department of Psychiatry and Behavioral Sciences.
  • Kramer JR; Department of Psychiatry.
  • Kuperman S; Department of Psychiatry.
  • Lai D; Department of Medical and Molecular Genetics.
  • Plawecki MH; Department of Psychiatry.
  • Porjesz B; Department of Psychiatry and Behavioral Sciences.
  • Schuckit MA; Department of Medical and Molecular Genetics.
  • Dick DM; Department of Psychiatry.
  • Bucholz KK; Department of Psychology.
  • Salvatore JE; Department of Psychology.
Psychol Addict Behav ; 36(4): 364-374, 2022 Jun.
Article in En | MEDLINE | ID: mdl-35617219
OBJECTIVE: To examine associations between alcohol use disorder (AUD), its psychiatric comorbidities, and their interactions, with marital outcomes in a diverse high-risk, genetically informative sample. METHOD: Participants included European ancestry (EA; n = 4,045) and African ancestry (AA; n = 1,550) individuals from the multigenerational Collaborative Study on the Genetics of Alcoholism (COGA) sample (56% female, Mage ∼ 41 years). Outcomes were lifetime marriage and divorce. Predictors included lifetime AUD, an alcohol problems polygenic score (PRS), and AUD comorbidities, including conduct or antisocial personality disorder (ASP), cannabis dependence/abuse (CAN), frequent tobacco use (TOB), and major depressive disorder (MDD). Mixed effect Cox models and generalized linear mixed effects models were fit. RESULTS: Among EA participants, those with AUD and CAN were less likely to marry (hazard ratios [HRs] 0.70-0.83, ps < 0.01). Among AA participants, those with AUD and TOB were less likely to marry (HRs 0.66-0.82, ps < 0.05) and those with MDD were more likely to marry (HR = 1.34, ps < 0.01). Among EA participants, AUD, CAN, TOB, and MDD were associated with higher odds of divorce (odds ratios [ORs] 1.59-2.21, ps < 0.01). Among AA participants, no predictors were significantly associated with divorce. Significant random effects indicated genetic and environmental influences on marriage, but only environmental factors on divorce. CONCLUSIONS: In a high-risk sample, AUD was associated with reduced likelihood of marriage in EA and AA individuals and increased risk of divorce in EA individuals. These associations were largely independent of comorbidities. Genetic and environmental background factors contributed to marriage, while only environmental background factors contributed to divorce. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Marijuana Abuse / Alcohol-Related Disorders / Depressive Disorder, Major / Alcoholism Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male Language: En Journal: Psychol Addict Behav Journal subject: PSICOLOGIA / TRANSTORNOS RELACIONADOS COM SUBSTANCIAS Year: 2022 Document type: Article Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Marijuana Abuse / Alcohol-Related Disorders / Depressive Disorder, Major / Alcoholism Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male Language: En Journal: Psychol Addict Behav Journal subject: PSICOLOGIA / TRANSTORNOS RELACIONADOS COM SUBSTANCIAS Year: 2022 Document type: Article Country of publication: