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Kinase-deficient BTK mutants confer ibrutinib resistance through activation of the kinase HCK.
Dhami, Kamaldeep; Chakraborty, Anirban; Gururaja, Tarikere L; Cheung, Leo W-K; Sun, Chaohong; DeAnda, Felix; Huang, XiaoDong.
Affiliation
  • Dhami K; Pharmacyclics LLC, an AbbVie Company, South San Francisco, CA 94080, USA.
  • Chakraborty A; Pharmacyclics LLC, an AbbVie Company, South San Francisco, CA 94080, USA.
  • Gururaja TL; Pharmacyclics LLC, an AbbVie Company, South San Francisco, CA 94080, USA.
  • Cheung LW; Pharmacyclics LLC, an AbbVie Company, South San Francisco, CA 94080, USA.
  • Sun C; AbbVie Inc., North Chicago, IL 60064, USA.
  • DeAnda F; AbbVie Inc., North Chicago, IL 60064, USA.
  • Huang X; Pharmacyclics LLC, an AbbVie Company, South San Francisco, CA 94080, USA.
Sci Signal ; 15(736): eabg5216, 2022 05 31.
Article in En | MEDLINE | ID: mdl-35639855
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Leukemia, Lymphocytic, Chronic, B-Cell / Proto-Oncogene Proteins c-hck Type of study: Prognostic_studies Limits: Humans Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2022 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Leukemia, Lymphocytic, Chronic, B-Cell / Proto-Oncogene Proteins c-hck Type of study: Prognostic_studies Limits: Humans Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2022 Document type: Article Affiliation country: Country of publication: