Your browser doesn't support javascript.
loading
Phase 1 and preclinical profiling of ESM-HDAC391, a myeloid-targeted histone deacetylase inhibitor, shows enhanced pharmacology and monocytopaenia.
Furze, Rebecca C; Molnar, Judit; Parr, Nigel J; Ahmad, Faiz; Henry, Yvette; Howe, David; Singh, Rajendra; Toal, Martin; Bassil, Anna K; Bernard, Sharon G; Davis, Robert P; Gibson, Adele; Maller, N Claire; Sharp, Catriona; Tough, David F; Prinjha, Rab K; Lewis, Huw D.
Affiliation
  • Furze RC; Research & Development, GlaxoSmithKline, Stevenage, Hertfordshire, UK.
  • Molnar J; Research & Development, GlaxoSmithKline, Stevenage, Hertfordshire, UK.
  • Parr NJ; Galapagos, Cambridge, UK.
  • Ahmad F; Research & Development, GlaxoSmithKline, Stevenage, Hertfordshire, UK.
  • Henry Y; MoonFire Consultancy Ltd, Hertfordshire, UK.
  • Howe D; Research & Development, GlaxoSmithKline, Stevenage, Hertfordshire, UK.
  • Singh R; Galderma R&D, Fort Worth, TX, USA.
  • Toal M; Research & Development, GlaxoSmithKline, Stevenage, Hertfordshire, UK.
  • Bassil AK; YMH-Management Ltd, Lancashire, UK.
  • Bernard SG; Research & Development, GlaxoSmithKline, Stevenage, Hertfordshire, UK.
  • Davis RP; SoseiHeptares, Cambridge, UK.
  • Gibson A; Research & Development, GlaxoSmithKline, Stevenage, Hertfordshire, UK.
  • Maller NC; GlaxoSmithKline, Collegeville, PA, USA.
  • Sharp C; Research & Development, GlaxoSmithKline, Stevenage, Hertfordshire, UK.
  • Tough DF; Conan Biopharma Consulting, Wokingham, UK.
  • Prinjha RK; Research & Development, GlaxoSmithKline, Stevenage, Hertfordshire, UK.
  • Lewis HD; Research & Development, GlaxoSmithKline, Stevenage, Hertfordshire, UK.
Br J Clin Pharmacol ; 88(12): 5238-5256, 2022 12.
Article in En | MEDLINE | ID: mdl-35655123
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Esterases / Histone Deacetylase Inhibitors Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Br J Clin Pharmacol Year: 2022 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Esterases / Histone Deacetylase Inhibitors Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Br J Clin Pharmacol Year: 2022 Document type: Article Affiliation country: Country of publication: